Vsevolod V. Gurevich
Springer Berlin Heidelberg
e druk, 2016
9783662522998
Arrestins - Pharmacology and Therapeutic Potential
Specificaties
Paperback, blz.
|
Engels
Springer Berlin Heidelberg |
e druk, 2016
ISBN13: 9783662522998
Rubricering
Onderdeel van serie
Handbook of Experimental Pharmacology
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
Specificaties
ISBN13:9783662522998
Taal:Engels
Bindwijze:paperback
Uitgever:Springer Berlin Heidelberg
Inhoudsopgave
<p>Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors.- Arrestin-biased GPCR Agonists.- Arrestin-1 Expression Levels, Rod Function and Health.- Protective Functions of Arrestin-1 in Photoreceptors.- Arrestin-4 and Cone Function.- Enhanced Phosphorylation-independent Arrestins and Gene Therapy.- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking.- Arrestins in Ubiquitination and Deubiquitination.- Arrestin Self-association.- Arrestin-dependent Activation of ERK and Src.- Arrestin-dependent Activation of JNK Family Kinases.- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization.- Arrestins in Cell Migration.- Arrestins in Host-pathogen Interactions.- Arrestin Regulation of Small GTPases.- GPCRs and Arrestins in Airways: Implications for Asthma.- Arrestins as Regulatory Signaling Hubs in Cancer Pathways.- Arrestins in Pain and Anesthesia.</p>