Regulation of Metabolic Processes by Covalent Modification of Proteins.- Introductory Remarks.- Phosphorylation—Dephosphorylation.- Glycogen Phosphorylase.- Studies on the Molecular Aspects of Phosphorylase b ? a Conversion.- Roles of 5’AMP and of its Analogs in the Activiation of Muscle Glycogen.- The Role of the ? and ? Subunits in the Regulation of Phosphorylase Kinase Activity.- Purification and Properties of Rabbit Muscle Phosphorylase Phosphatase.- The Use of Alternative Substrates in the Study of Phosphorylase Phosphatase and Phosphorylase Kinase.- Glycogen Synthetase.- Studies on Glycogen Synthase and its Control by Hormones.- Liver Glycogen Synthetase.- The Control of Glycogen Metabolism in the Liver.- Pyruvate Lèhydrogenase Complex.- Structure, Function and Regulation of the Mammalian Pyruvate Dehydrogenase Complex.- Regulation of Mammalian Pyruvate Dehydrogenases.- On the Mechanism of Insulin Action on Pyruvate Dehydrogenase Interconversion in Adipose Tissue.- Cyclic AMP Dependent and Independent Protein Kinases.- Protein Kinase Activity in Escherichia coli.- Molecular Characterization of Cyclic AMP-Dependent Protein Kinases Derived from Bovine Heart and Human Erythrocytes.- Phosphorylation of Non-Enzymatic Proteins: a) Ribosomal Proteins.- Ribosomal Proteins from Rabbit Reticulocytes: Numbers, Molecular Weights, Relative Amounts and Phosphorylation by Protein Kinases.- Phosphorylation of Ribosomal Proteins in Higher Organisms.- Phosphorylation of Non-Enzymatic Proteins: b) Muscle Proteins.- Phosphorylation and Dephosphorylation of Skeletal Muscle Troponin.- The Effect of Phosphorylation of Structural Muscle Proteins on the Actomyosin ATPase.- Phosphorylation of a Dogfish Skeletal Muscle Protein Related to Parvalbumin.- Adenylylation, Uridylylation and ADP-Ribosylation.- Glutamine Synthetase.- Fluorescence Studies of Glutamine Synthetase from Escherichia coli: ?-Adenylylated and Unadenylylated Enzymes.- Uridylylation of the PII Regulatory Protein in Cascade Control of Escherichia coli Glutamine Synthetase.- Escherichia coli RNA Polymerase.- T4-Induced Modification of Escherichia coli RNA Polymerase in vitro.- Diphtheria Toxin.- Covalent Alterations of Protein Structure in the Inhibition of Protein Synthesis by Diphtheria Toxin.- Other Types of Covalent Modifications.- SH-SS Interchange.- Interconversion of Nitrate and Nitrite Reductase of the Assimilatory Type.- Activation of Fructose 1,6-Diphosphatase by Disulfide Formation.- Limited Proteolysis.- Conversion of Neutral to Alkaline Fructose 1,6-Bisphosphatase by Proteolytic Mechanisms: Structure-Function Relationship.- Initiation of Physiological Function by Limited Proteolysis.- New Intracellular Proteases in Various Organs and their Regulation.- Rolle of Proteinases and their Inhibitors in the Regulation of Yeast Metabolism.- Protein-Protein Interactions.- Intra- and Interprotomeric Interactions between the Catalytic Regions of Aspartokinase I-Homoserine Dehydrogenase I from Escherichia coli K 12.- Regulation of L-Threonine Dehydrase via Ligand-Induced Oligomerization.- Renaturation Mechanism of Pyruvate Kinase of Saccharomyces carlsbergensis.- Interaction between Glutamate Dehydrogenase and Transaminase.- Hydrophobic Chromatography in the Study of Regulatory Enzymes.- Regulation of Enzymes in situ.- Author Index.
