Martin F. Fromm,
Richard B. Kim
Springer Berlin Heidelberg
2011e druk, 2013
9783642266454
Drug Transporters
Specificaties
Paperback, 454 blz.
|
Engels
Springer Berlin Heidelberg |
2011e druk, 2013
ISBN13: 9783642266454
Rubricering
Onderdeel van serie
Handbook of Experimental Pharmacology
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Specificaties
ISBN13:9783642266454
Taal:Engels
Bindwijze:paperback
Aantal pagina's:454
Uitgever:Springer Berlin Heidelberg
Druk:2011
Inhoudsopgave
From the contents.- Preface.- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport
