Part 4: Tissues .- Vascular.- Angiotensin II and Oxidative Stress. Angiotensin II and Atherosclerosis. Angiotensin II and Extracellular Matrix. Renin-Angiotensin Inhibitors and Vascular Effects. Brain / Nervous System.- Angiotensin Pathways and Brain Function. Involvement of the Renin-Angiotensin System in the Regulation of the Hypothalamic Pituitary Adrenol Axis. Angiotensin Actions on the Brain Influencing Salt and Water Balance. Angiotensin Receptor Signaling in the Brain: Ionic Currents and Neuronal Activity. Angiotensin, Neuroplasticity and Stroke.- Heart.- Role of Angiotensin II in Cardiac Remodeling. AT Receptor Pathophysiology in the Heart. Activation of the Renin-Angiotensin System after Myocardial Infarction.- Kidney and Adrenal Gland.- Angiotensin II, the Kidney and Hypertension. Angiotensin and Aldosterone Biosynthesis. Aldosterone - Clinical Aspects.- Part 5: Inhibition of the Renin-Angiotensin System.- ACE Inhibitors.- Interactions between the Renin-Angiotensin- and the Kallikrein-Kinin-Systems. ACE Inhibitors: Pharmacology.- AT1 Antagonists.- AT1 Receptor Antagonists : Pharmacology. Clinical Pharmacology of Angiotensin II Receptor Antagonists. Combined Blockade of the Renin Angiotensin System with ACE Inhibitors and AT1 Receptor Antagonists.- NEP/ACE Inhibitors.- Experimental and Clinical Aspects.- Part 6: Clinical Outlook.- Inhibitors of the RAS: Evidence-Based Medicine