Pier Paolo Pandolfi,
Peter K. Vogt
Springer Berlin Heidelberg
2007e druk, 2006
9783540345923
Acute Promyelitic Leukemia
Molecular Genetics, Mouse Models and Targeted Therapy
Specificaties
Gebonden, 274 blz.
|
Engels
Springer Berlin Heidelberg |
2007e druk, 2006
ISBN13: 9783540345923
Rubricering
Onderdeel van serie
Current Topics in Microbiology and Immunology
Levertijd ongeveer 8 werkdagen
Samenvatting
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
Specificaties
ISBN13:9783540345923
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:274
Uitgever:Springer Berlin Heidelberg
Druk:2007
Inhoudsopgave
APL as a paradigm in biomedical research: a journey towards the cure.- SUMO, the three Rs and cancer.- Arsenic Trioxide and APL: clinical and biological.- Treatment of APL by retinoids.- The PLZF gene of t(11;17)-associated APL.- Front line clinical trials and minimal residual disease monitoring in APL.- Targeting APL fusion proteins by peptide interference.- Emerging role for microRNAs in APL.- The design of selective and non-selective combination therapy for APL.- Histone deacetylase inhibitors in APL and beyond.- Monoclonal antibody therapy of APL.- Mouse Models of Acute Promyelocytic Leukemia.- Subject index