Lipoprotein(a)
Samenvatting
Lipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease. Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still very low among health care providers. Even cardiologists often overlook Lp(a), in part because Lp(a) is not as well-understood as other risk factors and treatment options are still very limited.
This book offers an authoritative and comprehensive overview of Lipoprotein(a). It provides an in-depth review of all aspects of Lp(a), from pathophysiology to metabolism. Chapters offer the reader a contemporary view of the important roles of Lp(a) as a risk factor for cardiovascular disease. In addition, this volume discusses the clinical implications of elevated Lp(a) and current and future therapies.
Lipoprotein(a) is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.
Specificaties
Inhoudsopgave
<p>1. History of Lp(a): Gert Uterman</p>
<p>2. Biochemistry: Structure, Composition: G.Kostner</p>
<p>3. Genetics of Lp(a): Florian Kronenberg</p>
<p>4. Genetic Variants and Isoforms : Stefan Coassin </p>
<p>5. Lp(a) and Lipid Oxidation: J.Witzum</p>
<p>6. Metabolism: D.Rader </p>
<p>7. Animal Models for Lp(a) Research: John Chapman</p>
<p>8. Pathophysiology: M.Koschinsky, Sally McvCormick</p>
<p>9. Possible Functions of Lp(a): P.Toth</p>
<p>10. Lp(a) and Atherosclerosis: H.Ginsberg </p>
<p>11. Role of Lp(a) as a CV Risk Factor: A.Catapano</p>
<p>12. Prospective Studies for Risk assessment: W. März </p>
<p>13. Lp(a) and Calcification: A.Langsted, PR Kamstrup</p>
<p>14. When to measure Lp(a): K.Kostner </p>
<p>15. Patients Perspectives: S.Tremulis</p>
<p>16. Role of Lpa in Clotting and Thrombosis: P.Moriarty</p>
<p>17. Lp(a) in Kidney Disease: H.Dieplinger</p>
<p>18. Lp(a) and FH: G.Watts </p>
<p>19. Epidemiology: B. Nordestgaard</p>
<p>20. Lp(a) and Mendelian Randomization: B.Ference, </p>
<p>21. Assays for Lp(a) Measurement: D.Sullivan</p>
<p>22. Lp(a) Standardization : S. Marcovina</p>
<p>23. Referenz Methods and Reference Material: Ch.Cobbaert</p>
<p>24. Therapy of elevated Lp(a): E.Stroes</p>
<p>25. Antisense Therapy : S.Tsimikas</p>
<p>26. Plasmapheretic Methods: U.Julius</p>
<p>27. Open Questions: G.Kostner</p>