<p>Section 1 defining the disease burden.- Pancreatic cancer in the population.- Pancreatic cancer biology.- Pancreatic cancer precursors (pancreas cysts).- Genetic syndromes and screening.- PDAC pathways.- Centralization of surgery and volume-outcome issues.- Education & training in pancreatic surgery.- research and progress in pancreatic surgery .- Section 2 Anatomy and physiology .- Anatomy and embryology.- Anatomical variants.- Vascular supply - Important arterial and venous variants.- Lymphatic drainage and variants.- Section 3 Symptoms and presentation (with pathophysiology) .- Intro: PDAC as a difficult disease to diagnose.- Jaundice .- cachexia and sarcopenia.- pain.- diabetes (new onset diabetes) Section 4 Imaging and preoperative staging .- Intro: goals of imaging /staging.- CT – protocol, pearls and pitfalls; resectable/borderline; locally advanced.- imaging after neoadjuvant therapy.- MRI – protocol, added value, cancer, cysts, accuracyetc.- Standard for reporting imaging results.- EUS – cancer, cysts, FNAC, biopsy, sens/spec, accuracy, markers.- ERCP - indications, stenting.- MDT - multidisciplinary team meeting; tumor board.- when a diagnosis can not be confirmed.- Section 5 Pathology and laboratory - reporting and research .- Intro: personalized medicine and precision medicine.- gross pathology - important aspects and standards.- histopathology - important aspects and standard template.- tissue sampling for research - fresh frozen.- sampling from formalin fixed tissue- aspects.- tumor markers (and biomarker research).- blood samples for research - liquid biopsy, proteomics etc.- Genomics, NGS, molecular classification.- Section 6 Chemotherapy and radiation therapy.- history of chemoradiotherapy in PDAC.- Available drugs - mechanisms, effect and side-effects.- role and mechanisms of radiotherapy.- Adjuvant chemotherapy – best evidence.- Neoadjuvant treatment in upfront resectable – principles and ongoing trials.- NAT in borderline or locally advanced - indiuction chemo.- Use of organoid modles to monitor/choose chemotherapy.- something here on novel therapies: immunotherapy etc? Section 7 Perioperative management .- Anesthesia and peri-op management.- Enhanced recovery – principles and standards.- Nutritional support and therapy in pancreatic surgery.- use of drains.- use of high-dependency unit/ICU/ward.- Section 8 Surgery .- Intro: Surgery as a curative apporach to PDAC.- Surgery for pancreatic head cancers.- Surgery for body and tail cancers.- central resections and enucleations.- Artery-first approach.- Minimal invasive pancreatic surgery.- Venous resection .- Arterial resection.- Reconstruction techniques, variations.- DP-CAR.- Extended resection criteria – multiorgan, M1 disease etc .- total pancreatectomy.- Lymphadenecomty.- Should we resect PDAC with solitary metastatis (liver, lung).- Research gaps.</p><br>
