<p>1. Enzyme Kinetics in Drug Metabolism – Fundamentals and Applications</p><p> Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie</p><p> </p><p>Part I. Fundamentals of Enzyme Kinetics</p><p> </p><p>2. Fundaments of Enzyme Kinetics</p><p> Eleanore Seibert and Timothy S. Tracy</p><p> </p><p>3. Different Enzyme Kinetic Models</p><p> Eleanore Seibert and Timothy S. Tracy</p><p> </p><p>4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance</p><p> Barbara Ring, Steven A. Wrighton, and Michael Mohutsky</p><p> </p><p>5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions</p><p> Michael Mohutsky and Stephen D. Hall</p><p> </p><p>6. Multi-Enzyme Kinetics and Sequential Metabolism</p><p> Larry C. Wienkers and Brooke VandenBrink</p><p> </p><p>7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics</p><p> Nigel J. Waters, R. Scott Obach, and Li Di</p><p> </p><p>Part II. Kinetics of Drug Metabolizing Enzymes and Transporters </p><p> </p><p>8. Enzyme Kinetics of Oxidative Metabolism – Cytochromes P450</p><p> Ken Korzekwa</p><p> </p><p>9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase</p><p> John T. Barr, Kanika Choughule, and Jeffrey P. Jones</p><p> </p><p>10. Enzyme Kinetics of Conjugative Enzymes – PAPS</p><p> Margaret O. James</p><p> </p><p>11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)</p><p> Jin Zhou and John Miners</p><p> </p><p>12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays</p><p> Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo</p><p> </p><p> </p><p>Part III. Modeling Considerations</p><p> </p><p>13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data – from in vitro Tools to Mechanistic Modeling</p><p> Aleksandra Galetin</p><p> </p><p>14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers</p><p> Joseph Bentz and Harma Ellens</p><p> </p><p>15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism</p><p> Nnena A. Finn and Melissa L. Kemp</p><p> </p><p>Part IV. Variability in Kinetics</p><p> </p><p>16. Variability in Human in vitro Enzyme Kinetics</p><p> Ying-Hong Wang and Christopher R. Gibson</p><p> </p><p>17. Sources of Interindividual Variability</p><p> Yvonne Lin and Kenneth E. Thummel</p><p> </p><p>Part V. Case Studies</p><p> </p><p>18. Case Study 1. Practical Considerations with Experimental Design and Interpretation</p><p> John T. Barr, Darcy R. Flora, and Otito Iwuchukwu</p><p> </p><p>19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies</p><p> Upendra A. Argikar and Swati Nagar</p><p> </p><p>20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies – Real Life Examples</p><p> Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie</p><p> </p><p>21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast</p><p> Ken Korzekwa</p><p> </p><p>22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development</p><p> Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou</p><p> </p><p>23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes</p><p>Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo</p><p> </p><p>24. Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors’ Experiences</p><p> Donald J. Tweedie</p>
