Measurements of DNA Damage, Cell Death, and Regulators of Cytotoxicity.- In Vitro Micronucleus Technique to Predict Chemosensitivity.- Cell Cycle and Drug Sensitivity.- TUNEL Assay as a Measure of Chemotherapy-Induced Apoptosis.- Apoptosis Assessment by the DNA Diffusion Assay.- PARP Cleavage and Caspase Activity to Assess Chemosensitivity.- Diphenylamine Assay of DNA Fragmentation for Chemosensitivity Testing.- Immunodetecting Members of the Bcl-2 Family of Proteins.- Correlation of Telomerase Activity and Telomere Length to Chemosensitivity.- Application of Silicon Sensor Technologies to Tumor Tissue In Vitro.- Overview of Tumor Cell Chemoresistance Mechanisms.- Flow Cytometric Monitoring of Fluorescent Drug Retention and Efflux.- Flow Cytometric Measurement of Functional and Phenotypic P-Glycoprotein.- Measurement of Ceramide and Sphingolipid Metabolism in Tumors.- Genomics, Proteomics, and Chemosensitivity.- Gene Expression Profiling to Characterize Anticancer Drug Sensitivity.- Identifying Genes Related to Chemosensitivity Using Support Vector Machine.- Genetic Manipulation of Yeast to Identify Genes Involved in Regulation of Chemosensitivity.- Real-Time RT-PCR (Taqman®) of Tumor mRNA to Predict Sensitivity of Specimens to 5-Fluorouracil.- Use of Proteomics to Study Chemosensitivity.- In VIVO Animal Modeling of Chemosensitivity.- Clinically Relevant Metastatic Breast Cancer Models to Study Chemosensitivity.- Orthotopic Metastatic (MetaMouse®) Models for Discovery and Development of Novel Chemotherapy.- Preclinical Testing of Antileukemic Drugs Using an In Vivo Model of Systemic Disease.- Assessing Growth and Response to Therapy in Murine Tumor Models.- Evaluation of Chemosensitivity of Micrometastases with Green Fluorescent Protein Gene-Tagged Tumor Models inMice.- 99mTc-Annexin A5 Uptake and Imaging to Monitor Chemosensitivity.- Magnetic Resonance Imaging of Tumor Response to Chemotherapy.- Metabolic Monitoring of Chemosensitivity with 18FDG PET.
