Glycobiology of the Immune Response
Samenvatting
Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein–binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state–of–the–art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system
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Specificaties
Inhoudsopgave
<p>Multifarious roles of sialic acids in immunity 16<br /> Ajit Varki and Pascal Gagneux</p>
<p>Siglecs as sensors of self in innate and adaptive immune responses 37<br /> James C. Paulson, Matthew S. Macauley and Norihito Kawasaki</p>
<p>Interleukin–2, Interleukin–7, T cell–mediated autoimmunity, and N–glycosylation 49<br /> Ari Grigorian, Haik Mkhikian and Michael Demetriou</p>
<p>T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival 58<br /> Mary C. Clark and Linda G. Baum</p>
<p>Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells 68<br /> Bo Pei, Jose Luis Vella, Dirk Zajonc and Mitchell Kronenberg</p>
<p>Gelectins in acute and chronic inflammation 80<br /> Fu–Tong Liu, Ri–Yao Yang and Daniel K. Hsu</p>
<p>Mechanisms underlying in vivo polysaccharide–specific immunoglobulin responses to intact extracellular bacteria 92<br /> Clifford M. Snapper</p>
<p>CD33–related siglecs as potential modulators of inflammatory responses 102<br /> Paul R. Crocker, Sarah J. McMillan and Hannah E. Richards</p>
<p>Sulfated glycans control lymphocyte homing 112<br /> Hiroto Kawashima and Minoru Fukuda</p>
<p>Acute phase glycoproteins: bystanders or participants in carcinogenesis? 122<br /> Eugene Dempsey and Pauline M. Rudd</p>
<p>Glycans, galectins, and HIV–1 infection 133<br /> Sachiko Sato, Michel Ouellet, Christian St–Pierre and Michel J. Tremblay</p>
<p>An evolutionary perspective on C–type lectins in infection and immunity 149<br /> Linda M. van den Berg, Sonja I. Gringhuis and Teunis B. H. Geijtenbeck</p>
<p>Integrated approach toward the discovery of glycol–biomarkers of inflammation–related diseases 159<br /> Takashi Angata, Reiko Fuijinawa, Ayako Kurimoto, Kazuki Nakajima, Masaki Kato, Shinji Takamatsu, Hiroaki Korekane, Cong–Xiao Gao, Kazuaki Ohtsubo, Shinobu Kitazume and Naoyuki Taniguchi</p>
<p>Novel roles for the IgG Fc Glycan 170<br /> Robert M. Anthony, Fredrik Wermeling and Jeffrey V. Ravetch</p>
<p>The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? 181<br /> Dianne Cooper, Asif J. Iqbal, Beatrice R, Grittens, Carmela Cervone and Mauro Perretti</p>
<p>Engineering cellular trafficking via glycosyltransferase–programmed stereosubstitution 193<br /> Robert Sackstein</p>
<p>The expanding role of 2–3 sialylation for leukocyte trafficking in vivo 201<br /> Markus Sperandio</p>
<p>Beyond glycoproteins as galectin counterreceptors: effector T cell growth control of tumors via ganglioside GM1 206<br /> Robert W. Ledeen, Gusheng Wu, Sabine André, David Bleich, Guillementte Huet, Herbert Kaltner, Jürgen Kopitz and Hans–Joachim Gabius</p>
<p>Online only</p>
<p>Polarization of host immune responses by helminth–expressed glycans<br /> Donald Harn Jr., Smanla Tundup and Leena Srivastava</p>
<p>Carbohydrate–recognition in the immune system: contributions of NGL–based microarrays to ligand discovery<br /> Ten Feizi</p>
<p>Diversity in recognition of glycans by F–type lectins and galectins: molecular, structural, and biophysical aspects<br /> Gerardo R. Vasta, Hafiz Ahmed, Mario A. Bianchet, José A. Fernández–Robledo and L. Mario Amzel</p>