Purine and Pyrimidine Metabolism in Man VI

Biochemistry of Enzymes in Purine and Pyrimidine Metabolism.- Rat Liver Phosphoribosylpyrophosphate Synthetase: Existence as Heterogenous Aggregates and Identification of the Catalytic Subunit.- Potent and Specific Inhibitors of Mammalian Phosphoribosylpyrophosphate PRPP Synthetase.- PRPP and Purine Nucleotide Metabolism in Human Lymphoblasts with Both PRPP Synthase Superactivity and HGPRT Deficiency.- Purification of Rat Liver Amidophosphoribosyltransferase.- Paradoxical Effects of Glucagon on De Novo Purine Synthesis in Rat Liver: In Vitro Phosphorylation of Amidophosphoribosyltransferase.- Proliferative Effect of Insulin by Selective Gene Expression in Purine Metabolic Pathway in Primary Cultured Rat Hepatocytes.- Purine De Novo Synthesis and Inosinic Branch Point In Vivo in Different Tissues: A Biomathematical Model.- The Inosinic Branch Point and Its Hormonal Regulation: Evaluation through a Mathematical Model.- Kinetic Properties of IMP Dehydrogenase Purified from Rat Hepatoma 3924A.- Two Distinct target Sites on IMP Dehydrogenase in Chemotherapy.- A Study of Adenosine Deaminase and Its Conversion Factor in Human Serum.- Cytidine Deaminase from Human Spleen.- AMP Deaminase and Thymidine Kinase Deficiencies in A Mutant Mouse S49 Cell Clone.- Properties of Highly Purified Human T lymphoblast (MOLT-4) Deoxycytidine Kinase.- Cell Cycle Regulation of Ribonucleotide Reductase M2 Subunit Specific RNA in Wild Type and Mutant S49 Cells.- Phosphocreatine as a Possible Modulator of the Adenylate Pool.- Regulation of Soluble 5?-Nucleotidase I from Rabbit Heart.- Purine 5?-Nucleotidase — Its Reestimated Subunit Molecular Mass and Immunocytochemical Localization in Chicken Liver.- The Application of Affinity Chromatography for the Separation of “High Km” and “Low Km” 5?-Nucleotidase and Other AMP Metabolizing Enzymes.- Evidence for “Low Km” and “High Km” Soluble 5?-Nucleotidase in Human Tissues and Rat Liver.- Low 5?Nucleotidase Activity in Mononuclear Cells of Patients with Defect T-Cell function.- Stimulation by Glycerate 2,3-Bisphosphate: a Common Property of Cytosolic Purine 5?-Nucleotidase in Various Tissues.- Functional Characterization of Ecto-5?-Nucleotidase (Ecto-5?-NT) Positive and Negative Human Lymphocytes.- Anti-5?-Nucleotidase Antibodies Cause Human Peripheral Blood T Cells to Proliferate.- Erythrocyte Pyrimidine 5?-Nucleotidase: HPLC Assay, Observation on the Enzyme behavior.- Structure of Xanthine Dehydrogenase from Chicken and Rat Liver. Chemical Modification of NAD Binding Site with 5?-FSBA.- Interconversion between NAD-Dependent and O2-Dependent Types of Rat Liver Xanthine Dehydrogenase and Difference in Kinetic amd Redox Properties between Them.- Mammalian Xanthine Oxidoreductase — A Unique Enzyme among Hypoxanthine Hydroxylating Enzymes in Vertebrates.- Heterogeneity of the Toxic Mechanisms of Methylthioadenosine in Methylthioadenosine Phosphorylase Deficient Murine Lymphoma Cells.- Improved Assay Method of dTMP Synthase in Rat Liver and Its Application to Human Lung Cancer Cells.- Toxic Mechanisms of Deoxynucleosides.- Adenosine Deaminase Activity in Recipients of Bone Marrow from Immunodeficient Mice Homozygous for the Wasted Mutation.- Utilization of 2?-DeoxyNAD for ADP-ribose Transfer Reactions.- Profound Toxicity of Deoxyadenosine and 2-Chlorodeoxyadenosine toward Human Monocytes In Vitro and In Vivo.- The Mechanism of 2-Chlorodeoxyadenosine-lnduced Cell Death.- Artefacts due to Radiation-Induced Cell Damage in Pulse-Labeling Experiments Using Tritiated Nucleic Acid Precursors.- Reduced Purine Nucleotide Content and Poly(ADP-Ribose) Synthetase Activity in HPRT-Deficient Human Lymphoblasts.- Inability of Poly-ADP-Ribosylation Inhibitors to Protect Peripheral Blood Lymphocytes from the Toxic Effects of ADA Inhibition.- Characterization of Poly(ADP-ribose) Polymerase with Human Autoantibodies.- Mechanism of ATP Catabolism Induced by Deoxyadenosine and Other Nucleosides in Adenosine Deaminase-lnhibited Human Erythrocytes.- DeoxyGTP Accumulates in Thymocytes, but not in T or B Lymphocytes in Simulated PNP Deficiency.- The Mechanism of Deoxyguanosine Mediated Toxicity in Proliferating Human Peripheral Blood T Lymphocytes.- Anti-Cancer Purine and Pyrimidine Analogs, Basic Research.- Metabolism of Guanosine and Its C-8 Substituted Analogues in Human Lymphocyte Cytoplasm.- Selective Toxicity of Purine Nucleosides to Human Leukaemic Cells.- Recovery of the Acitivities of IMP Dehydrogenase and GMP Synthase after Treatment with Tiazofurin and Activicin in Hepatoma Cells In Vitro.- Channeling of IMP into Guanylate Synthesis in the Growth Program of Hepatoma 3924A Cells.- Incorporation of 5-Fluorouracil into Nucleotide Sugars and the Effect on Glycoconjugates in Rat Hepatoma Cells and Hepatocytes.- Transport and Intracellular Metabolism of Fluorinated Pyrimidines in Cultured Cell Lines.- Fluoropyrimidine Metabolism in Human Head and Neck Cancer Xenografts and Murine Colon Tumors.- Reduction of Ara-C Cytotoxicity in HL 60 Cells by Addition of Deoxycytidine, Cytidine or Increased Level of Cytidine Deaminase.- Intracellular Pharmacokinetics of N4-Behenoyl-1-?-D-Arabinofuranosyl-cytosine.- Sequential Combination of Methotrexate and 1-?-D-Arabinofuranosyl-cytosine Shows Synergistic Effect on the Generation of DNA Strand Breaks in a Human Promyelocytic Cell Line.- Synergistic Interaction between Etoposide and 1-?-D-Arabinofuranocyl-cytosine.- Ara-CTP Metabolism Following Hydroxyurea or Methotrexate Treatment in Human Leukemia Cell Lines.- Relationship between Intracellular dCTP/Ara-CTP Ratio and Cytotoxic Effect of Ara-C.- The Relationship between Dihydroorotic Acid Dehydrogenase and In Vitro and In Vivo Cytostatic Effects of Brequinar Sodium (DUP-785; NSC 368390).- Estimation of the In Vitor and In Vivo Inhibitory Effects of Antifolates upon Thymidylate Synthase (TS) in Whole Cells.- Anti-Viral Purine and Pyrimidine Analogs.- Effects of 3?-Azido-3?-Deoxythymidine and the Deoxynucleoside Triphosphate Pools of Cultured Human Cells.- 2-Halo-2?,3?-Dideoxyadenosines: Metabolically Stable Dideoxynucleosides with Activity against the Human Immunodeficiency Virus (HIV).- 3?-Azido-3?-Deoxythymidine and Acyclovir: Antiviral Nucleoside Analogues with Unusual Cell Membrane Permeation Properties.- The Antiretroviral and Cytostatic Activity, and Metabolism of 3?-Azido-2?,3?-Dideoxythymidine, 3?-Fluoro-2?,3?-Dideoxythymidine and 2?,3?-Dideoxycytidine are Highly Cell Type-Dependent.- Dideoxycytidine Metabolism in Wild Type and Mutant CEM Cells Deficient in Nucleoside Transport or Deoxycytidine Kinase.- Adenosine and Adenosine Receptors.- Coordinate Regulation of Adenosine A1 and A2 Receptors.- A1 and A2 Adenosine Receptors in Synovial Cells from Patients with Rheumatic Diseases.- Use of Purine Nucleotide and Nucleoside Metabolising Enzymes as Tools to Determine the Presence of Purinergic Nerve Transmission in Smooth Muscle.- Influence of Succinylpurines on the Binding of Adenosine to a Particulate Fraction of Rat Cerebral Cortex.- Protective Effects of Cyclohexyladenosine Following Cerebral Ischemia in the Gerbil Hippocampus.- Differential Expression of Ecto-Nucleotide Metabolic Enzymes during Immunoglobulin Gene Rearrangements in Human Pre-B-Cells.- Purine Metabolism in Various Cells.- Optimised Conditions for the Routine HPLC Separation of Nucleotides in Cell Extracts.- Qualitative and Quantitative Studies on the Nucleotides of Intestinal Mucosa.- Relationship between Extracellular and Intracellular Nucleotide Metabolism in Human Lymphocytes.- Effect of Some Purine Metabolites Contained in Oyster on Platelet Aggregation.- Enzymes of Purine Nucleotide Metabolism in Mature Cultures of Rat Brain Neurons.- Nucleotide Pyrophosphatase Antagonizes Contractions due to the Twitch Component of the Sympathetic Nerve Response and to Applied ATP in the Guinea-Pig Vas Deferens.- Regulation of Purine Nucleotide Metabolism in Hypoxic Liver and Intestine of Rats: Radical Scanvenging Effects of Allopurinol and Oxypurinol.- Localization of Xanthine Dehydrogenase in Liver.- Determination of Allantoin in Mammalian Tissues.- Nucleoside Transport.- Characterization of Nucleoside Transport during Leukemic Cell Differentiation.- Exprssion of a Novel High Affinity Purine Base Transport System in Mutant Mouse S49 Cells does not Require a Functional Nucleoside Transporter.- Characterization of a Mutant Clone of Leishmania Donovani Deficient in Folate Transport.- Influence of the Temperature on Hypoxanthine Transport through Human Erythrocyte Membranes.- Adenine Uptake by Human Erythrocytes.- Contributors.