Secretory Immunity and Infection

Introductory Address.- New Areas Arising from Studies of Secretory Immunity.- Session I: Cellular Aspects of Mucosal Immunity.- Generation of Clonal and Isotype Diversity.- Cellular Parameters of the IgA Response.- Lymphatic Physiology and Secretory Immunity.- Development of the IgA System in the Mammary Gland.- Effect of Anti-IgD Serum on Immune Responses.- A Common Mucosal Immunologic System Involving the Bronchus, Breast and Bowel.- Discussion I.- Migration Pathways of T Lymphocytes in the Small Intestine.- Cell-Mediated Immunity on Secretory Surfaces.- Immunoglobulin A Production by Human Colostral Cells: Quantitative Aspects.- Immunologic Aspects of Human Colostrum and Milk: Interaction with the Intestinal Immunity of the Neonate.- Discussion II.- Session II: Induction of a Secretory Immune Response.- Remote-Site Stimulation of Secretory IgA Antibodies Following Bronchial and Gastric Stimulation.- Development of Humoral Antibody Following the Ingestion of Soluble Protein Antigen by Passively Immunized Animals.- Elimination of Escherichia coli K88 Adhesion Determinant by Antibody in Porcine Gut and Mammary Secretions Following Oral Immunization.- Cellular Aspects of the Murine Anti-Hapten IgA Response.- Discussion I.- Characterization of Immunoglobulin-Containing Cells in the Submandibular Gland of the Rat After Local Immunization.- Secretory IgA Antibodies to Enterobacterial Virulence Antigens: Their Induction and Possible Relevance.- Induction of Secretory Antibodies in Humans Following Ingestion of Streptococcus mutans.- Concept of the Local and Common Mucosal Immune Response.- Discussion II.- Session III: Biosynthesis and Transport of Secretory Antibodies.- T-Cell Regulation of Murine IgA Biosynthesis.- Molecular— Cellular Interactions in the Secretory IgA System.- Further Evidence for a Role of Secretory Component (SC) and J Chain in the Glandular Transport of IgA.- Influence of Parenteral Immunization in Rabbits on the Penetrability of Oral Mucosa for Macromolecules.- Role of the Liver in the Rat Intestinal s-IgA System.- Transport of Oligomeric IgA of Systemic Origin Into External Secretions.- Discussion I.- Session IV: Caries Immunity.- A. Animal Studies.- Effective Immunity to Dental Caries: Selective Induction of Secretory Immunity by Oral Administration of Streptococcus mutans in Rodents.- Cross-Protective Aspects of Glucosyltransferase Antigens in the Hamster Caries Model.- Antigens of Streptococcus mutans Implicated in Virulence-Production of Antibodies.- The Effect of Cyclosporin A on Dental Caries in Rats Monoassoeiated with Actinomyces viscosus NY 1.- Passive Immunization with Antisera to Streptococcus mutans in the Prevention of Caries in Rhesus Monkeys.- Antibody Binding of Glucosyltransferase Enzyme Preparations from Homologous and Heterologous Serotypes of S. mutans.- Daucus carrota (Carrot) — A Selective Bacteriosorbent.- Discussion I.- B. Human Studies.- Studies of Secretory IgA in Caries-Resistant and Caries-Susceptible Adults.- Antibodies Reacting with Streptococcus mutans in Secretions from Minor Salivary Glands in Humans.- Salivary IgA Antibodies to Antigens from Streptococcus mutans in Human Dental Caries.- Antibodies Against Streptococcus mutans and Glucosyltransferases in Caries-Free and Caries-Active Military Recruits.- Immunoglobulins and Antibodies in Plaque Fluid and Saliva in Two Populations with Contrasting Levels of Caries.- Discussion I.- Secretory Immunity and Immunodeficiency.- The Partial Isolation and Function of Salivary Factors Which Interact with the Complement System: A Possible Role in Mucosal Immunity.- Discussion II.- Session V: Studies of Virulence and Immunity.- Adhesion and Chemotaxis as Determinants of Bacterial Association with Mucosal Surfaces.- The Role of Antigen Form and the Induction of an Intestinal Immune Response to Cholera Toxin/Toxoid in Rats.- Motility of the Pathogen and Intestinal Immunity of the Host in Experimental Cholera.- Discussion I.- Prevention of Bacterial Infections of Mucosal Surfaces by Immune Secretory IgA.- Studies on Oral Adjuvants Against Murine Salmonellosis.- Cell Mediated Immune Responses to Bacterial Antigens on Human Mucosal Surfaces.- Assay and Properties of IgA Protease of Streptococcus sanguis.- Discussion II.- Session VI A: Structural and Functional Studies of Secretory Immunoglobulins.- A. Structure.- A Comparison of Secretory Component — Immunoglobulin Interactions Amongst Different Species.- Serologic and Structural Comparisons of Rabbit IgA Allotypes.- Milk Precipitins, Circulating Immune Complexes and IgA Deficiency.- Regulation by Sex Hormones of Immunoglobulins in Rat Uterine and Vaginal Secretions.- Discussion.- B. Functional Aspects.- Effect on Rat IgA Synthesis by Isotypic Suppression with an Anti-Rat Delta Heavy Chain Serum.- Immunoglobulin A in Secretions from the Lower Human Respiratory Tract.- Measurement of IgA Memory to 2,4-Dinitrophenyl (DNP) in the Sera of Adoptive Recipient Rats Using the Amplified Elisa.- Human Mucosal Lymphocytes — Memory for ‘Recall’ Antigens and Non-Specific Suppression by T-Lymphocytes.- Response of Anamnestic IgA-Producing Cells in the Mouse Gut After Repeated Intragastric Immunization.- Detection of IgA Anti-Escherichia Coli Plasma Cells in the Intestine and Salivary Glands of Pigs Orally and Locally Infected with E. Coli.- Discussion.- Session VI B: Antigens of Oral Bacteria.- A. Lipoteichoic Acid and Other Antigens.- Lipoteichoic Acid — The Key to the Adhesiveness of Sucrose Grown Streptococcus Mutans.- Amphipathic Antigens of Oral Microorganisms — Immunogenicity and Other Biological Properties.- Effect of Growth Conditions on the Antigenic Components of Streptococcus mutans and Lactobacilli.- Modification of In Vitro Adherence of Streptococcus mutans by Plant Lectins.- Search for Cross-Reacting Antigens of Oral Acidogenic Bacteria and Members of the Normal Intestinal Flora.- Discussion I.- Genetic Alterations of Streptococcus mutans’ Virulence.- Use of Mutants in the Elucidation of Virulence of Streptococcus mutans.- Wall Carbohydrate Antigens of A. Israelii.- Fimbriae of Actinomyces viscosus T14V: Their Relationship to the Virulence-Associated Antigen and to Coaggregation with Streptococcus sanguis 34.- Preliminary Results in the Immunization of Irus Monkeys Against Dental Caries.- Discussion II.- Session VII: Antigens of Oral Bacteria.- B. Studies with Glucosyltransferases.- Streptococcus mutans Dextransucrase: Phosphoglycerides and the Detection of Inhibitory Antibodies in Sera.- Interaction of Streptococcus mutans Glucosyltransferases with Antibodies.- Dextran/Glucan Binding by Streptococcus mutans: The Role of Molecular Size and Binding Site in Agglutination.- Multiple Forms of Dextran-Binding Proteins from Streptococcus mutans.- Discussion.- General Discussion.- Session VII: Antigens of Oral Bacteria Chairman: Arnold S. Bleiweis.- C. Surface Glucans.- Dextran Receptors as Immunogens in Caries Prophylaxis.- Antigenicity and Immunogenicity of Cell-Associated Glucans from Streptococcus mutans.- A Comparison of the Phenol Water and Rantz and Randall Teichoic Acid Antigens in Group H Streptococci.- Turnover and Excretion of Streptococcal Surface Components.- Discussion.- Session VIII: Ecological Considerations.- Fluorescence Quantitation of S-IgA in Parotid Saliva and of S-IgA Bound to Oral Microorganisms.- Antigenic Variation in Populations of Oral Streptococci.- Salivary Immunoglobulins in Diseases Affecting Salivary Glands.- Whole Saliva Proteases: Development of Methods for Determination of Origins.- Extrachromosomal Gene Systems in Streptococcus mutans.- Bacterial Adherence Related to Agglutination and Surface Film Formation.- Discussion.- Report of the Summation Committee: Recommended Areas for Future Research.