Contemporary Topics in Immunobiology

1. T Cell Control of Antibody Production.- Evidence for a Suppressor Effect of T Cells.- Specific Effects.- Nonspecific Effects.- Effects in the Absence of Viable B Cells.- Suppressor Macrophages.- Suppressor Animals.- Interactions Between T Cell Subpopulations.- Subclasses of B Cells.- Meaning of “Thymus Independency”.- T Cell Discrimination of Signals.- Role in Genetically Controlled Responsiveness to Antigen.- Role of Physical Characteristics of Antigen.- Role of Antibody.- Role in Antigen Dose Effects.- Do Tolerant Cells Exist?.- Meaning in Life.- Possible Models.- Summary.- Abbreviations.- Acknowledgments.- References.- 2. Short-Term and Chronic Allotype Suppression in Mice.- Allotype Suppression in Rabbits.- Allotype Suppression in Mice.- Immunoglobulin Allotypes in Mice.- Origins of Immunoglobulins in Young Mice.- Short-Term Allotype Suppression.- Specificity of Suppression.- Suppression of Antibody Carrying the Suppressed Allotype.- Chronic Allotype Suppression.- Immunologic Abnormalities of SJL/J Mice.- Chronic Allotype Suppression in (SJL X BALB/c) Hybrids.- SJL Genome and Chronic Suppression.- Active Factor Responsible for Chronic Suppression.- Mixture-Transfer Assay for Suppression.- Suppressor T-Cells in Lymphoid Tissues.- Chronic Suppression by Transfer of Suppressor Cells to Young Syngeneic Hybrids.- Role of the Thymus in Generation and Maintenance of Suppression.- Mechanism of Chronic Allotype Suppression.- B-CelI Differentiation.- T-Cell Functions.- Suppression of Immunoglobulins in Other Systems.- Suppressor T-Cells as Killers?.- Suppressor T-Cells as Regulators?.- Acknowledgments.- References.- 3. On the Relationship Between Cellular and Humoral Antibodies.- Cellular and Humoral Antibodies Produced by B Cells.- Identification of the Antigen-Binding, Cellular Receptor as an Immunoglobulin.- Orientation and Chemistry of Membrane-Bound Immunoglobulin.- Distribution and Density of Membrane-Bound Ig or Antigen-Binding Receptors.- The Relationship Between Immunoglobulin Heavy Chain Class in.- Receptor and Humoral Antibody Produced by the Same Cell.- The Antigen-Binding Specificity of Surface Antibodies in Comparison to Humoral Antibodies Produced by the Same Cell.- A Speculative Comparison of the Competitive Capacity for Antigen of Cellbound vs. Humoral Antibodies.- The Role of Cellular Antibodies in the Induction of Humoral Antibody Formation.- Cellular and Humoral Antibodies Produced by T Cells.- Acknowledgments.- References.- 4. T Cell Modification of B Cell Responses to Antigen in Mice.- Experimental T Cell Deficiencies.- Nonspecific.- Specific (Antigen-Induced).- “T Cell Independent” Responses of B Cells.- Class of Antibody Produced.- Fate of B Cells.- Responses to Persisting Antigens.- Conclusions.- Abbreviations.- Acknowledgments.- References.- 5. Genetic Control of Antibody Responses to Myeloma Proteins of Mice.- Immunoglobulin Allotypes of the Mouse.- Genetic Control of the Immune Response to BALB/c IgA Myeloma Proteins.- Genetic Control of the Immune Response to BALB/c IgG Myeloma Proteins.- Genetic Control of the Immune Response to BALB/c IgH (?2 b) Myeloma Proteins.- Mapping of Ir Genes in the H-2 Complex.- Function of Ir Gene Products.- Acknowledgment.- References.- 6. Histocompatibility Systems, Immune Response, and Disease in Man.- HL-A and H-2.- H-2 and Murine Leukemia.- Immune Response Genes.- HL-A and Disease.- Serological Inadequacy in the Definition of HL-A Specificities.- The Definition of the Disease Itself.- Statistical Evaluation of an Association Between an HL-A Specificity and a Disease.- Leukemias.- Lymphomas.- Immunopathic Diseases.- Genetic Diseases.- Cancer (Other than Lymphomas).- Infectious Diseases.- HL-A and Immune Responses.- Nature of Association Between HL-A and Disease.- References.- 7. Antigen-Binding Receptors on Lymphocytes.- Methods for Measuring ABC.- ABC in Nonimmune Animals.- ABC in Immune Animals.- ABC in Tolerance.- Summary.- References.- 8. Modification of B Lymphocyte Differentiation by Anti-immunoglobulins.- Suppression of First Stage B Lymphocyte Differentiation: In Vivo Models.- Suppression of Immunoglobulin Synthesis in Mice.- Suppression of Immunoglobulin Synthesis by Anti-µ Antibodies.- Treatment of Mice with Antibodies to ?1, ?2, and a Determinants.- Suppression of IgG1.- Suppression with Anti-IgG2 and Anti-IgA.- Evidence that IgA Committed Cells Are Derived from IgG Bearing Precursors.- Suppression of Second Stage Differentiation by Anti-Immunoglobulins: In Vitro Models.- Conclusion.- Acknowledgments.- References.- 9. The Roles of T and B Lymphocytes in Self-Tolerance and Autoimmunity.- Tolerance in T and B Lymphocytes.- T Cell Helper Effects in Immune Responses.- Autoantigen-Binding Lymphocytes in Normal Subjects.- Allogeneic Cell Stimulation, Adjuvants, and Autoantibody Formation.- Virus Infections.- Effects of Haptens and Drugs.- Control of Immune Responses by T Cells.- Congenital Virus Infections.- General Comment.- References.- 10. Immunological Studies of Nude Mice.- Genetics.- Cellular Defects.- The Thymus.- Thymocyte Precursors.- Thymus-Derived Lymphocytes.- Thymus Independent Lymphocytes.- Response to Mitogens.- Mitogenic Response to Allogeneic Cells.- Mitogenic Responses to Antigens.- Antigen Binding.- Immunoglobulin Levels.- Response to Thymus Independent Antigens.- Response to Thymus Dependent Antigen.- Sheep Red Blood Cells.- Other Antigens.- Contact Sensitivity.- Cell Mediated Cytotoxicity.- Skin Grafts.- Tumor Grafts.- Spontaneous Tumors.- Effect of Mitogens on Antibody Production In Vitro.- Effect of Thymocytes and Thymus-Derived Cells on Antibody Production In Vitro.- Thymus Grafts In Vivo.- Comments.- Acknowledgments.- References.