Session I — Chairman, John Schenkman.- 1.- Partial Purification and Separation of Multiple Forms of Cytochrome P-450 and Cytochrome P-448 from Rat Liver Microsomes.- Biochemical Characterization of Highly Purified Cytochrome P-450 and Other Components of the Mixed Function Oxidase System of Liver Microsomal Membranes.- Immunochemical and Compositional Comparison of Cytochromes P-450cam of Pseudomonas putida and P-450LM of Phenobarbital-Induced Rabbit Liver Microsomes.- Immunochemical and Functional Similarities and Differences among Iron-Sulfur Proteins Involved in Mammalian Steroidogenesis.- General Discussion.- Peisach, Coon, Jerina, Schenkman, Levin, Peterson, Ballou, Kamin, Baron, Masters.- 2.- Comparison of the Induction Course, Biophysical Chemical Interactions and Photochemical Action Spectra of Pheobarbital- and 3-Methylcholanthrene-Induced Hepatic Microsomal P-450.- Cytochrome P-450 in the Activation and Inactivation of Carcinogens.- Effect of Cyclic AMP on the Phenobarbital Induced Increase in Cytochrome P-450 and Hypertrophy of the Endoplasmic Reticulum of the Rat Liver.- Evidence for the Activation of 3-Methylcholanthrene as a Carcinogen In Vivo and as a Mutagen In Vitro by P1-450 from Inbred Strains of Mice.- Increased Translation as a Result of Elevated Initiation Factor Activity after Administration of 3-Methylcholanthrene.- General Discussion.- Holtzman, Hutterer, Coon, Cooper, Schenkman, Jerina, Peisach, Remmer, Schleyer, Cinti, Nebert, Bresnick, Narasimhulu, Orrenius.- Session II: Chairman, Daniel Nebert.- 1.- Optical and EPR Studies of Partially Purified Rabbit Liver Cytochrome P-450.- Studies on the Spin State of 3-Methylcholanthrene-Induced Cytochrome P-450 from Rat Liver.- An Analysis of the Optical Titrations of the 430 and 455 nm Chromophores of Ethyl Isocyanide Complexes of Mammalian Hepatic Cytochrome P-450.- Implications of Ligand Modified Spectra of Cytochrome P-450 Associated with Pregnenolone Synthesis in Mitochondria from Corpus Luteum.- General Discussion.- Mannering, Witmer, Lu, Snyder, Levin, Nebert, Holtzman, Remmer, Vore, Narasimhulu, Stern, Kamin, Peisach, Schenkman, Hildebrandt, Coon.- 2.- Studies on the Interaction of Water with Microsomal Cytochrome P-450.- Drug Metabolism in Isolated Rat Liver Cells.- Role of Phospholipids in Adrenocortical Microsomal Hydroxylation Reactions: Activation of Lipid-Depleted Microsomal Preparations by Non-Ionic Detergents.- On the Structure of Putidaredoxin and Cytochrome P-450cam, and Their Mode of Interaction.- Metabolic Control of Cytochrome P-450cam.- General Discussion.- Stern, Peterson, Dus, Peisach, Bresnick, Orrenius, Holtzman, Remmer, Cinti, Thurman, Nebert, Narasimhulu, Coon, Lu, Jerina.- Session III — Chairman, Charlotte Witmer.- Relationship between Microsomal Hydroxylase and Glucuronyltransferase.- A Possible Role of Copper in the Regulation of Heme Biosynthesis through Ferrochelatase.- Mixed Function Oxidation and Intermediary Metabolism: Metabolic Interdependence in the Liver.- Dissociation of Microsomal Ethanol Oxidation from Cytochrome P-450 Catalyzed Drug Metabolism.- General Discussion.- van der Hoeven, Remmer, Mannering, Thurman, Coon, Vatsis, Orrenius, Schenkman, Kamin, Bresnick, Wagner, Hildebrandt, Thurman.- Session IV : Chairman, Otto Rosenthal.- Interaction between Microsomal Electron Transfer Pathways.- Role of Cytochrome b5 in the NADH Synergism of NADPH-Dependent Reactions of the Cytochrome P-450.- The Role of Cytochrome b5 in Cytochrome P-450 Enzymes.- Role of Cytochrome b5 in NADPH- and NADH-Dependent Hydroxylation by the Reconstituted Cytochrome P-450- or P-448-Containing System.- The Role of Cytochrome b5 in Mixed Function Oxidations: Effect on Microsomal Binding of the Hemoprotein on Hepatic N-Demethylations.- Comparison of Methods to Study Enzyme Induction in Man.- General Discussion.- Holtzman, Lu, Mannering, Kamin, Lichtenberger, Rosenthal, Hildebrandt, Schleyer, Narasimhulu, Orrenius, Schenkman, Levin, Sasame, Cinti, Lotlikar.- Contributors.- Author Index.
