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Human Gametes and Preimplantation Embryos

Assessment and Diagnosis

Specificaties
Gebonden, 306 blz. | Engels
Springer New York | 2013e druk, 2013
ISBN13: 9781461466505
Rubricering
Springer New York 2013e druk, 2013 9781461466505
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

In recent years, the advancing science and increasing availability of assisted reproduction have given new hope to infertile couples. However, the use of IVF and ART has also led to marked increases in the number of multiple-infant live births. This poses a public health concern, as these neonates have a higher rate of pre-term delivery, compromising their survival chances and increasing their risk of lifelong disability. By optimizing the selection of gametes and embryos with high probabilities of implantation, it is possible to reduce the number of embryos transferred and, by extension, the number of high-risk multiple gestations, while maintaining or increasing pregnancy rates.

Human Gametes and Preimplantation Embryos: Assessment and Diagnosis provides a broad yet concise overview of established and developing methodologies for assessment of gamete and embryo viability in assisted reproduction. This book elucidates the best practices for precisely selecting viable specimens based on morphology and cleavage rate and covers the spectrum of emerging adjunctive technologies for predicting reproductive potential. The authors present their extensive knowledge of “omics” approaches (genomics, transcriptomics, proteomics, and metabolomics), with unbiased delineation of the associated advantages and potential pitfalls. This valuable clinical resource is well suited to infertility specialists, Ob/Gyn physicians, IVF laboratory technicians, and researchers in the fields of embryology and reproductive medicine.

Specificaties

ISBN13:9781461466505
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:306
Uitgever:Springer New York
Druk:2013

Inhoudsopgave

<p>1. Current Practices and Regulations for Embryo Transfer Worldwide: Implications on IVF Outcome </p><p>Baris Ata and Emre Seli</p><p>2. Analysis of the Zona Pellucida as an Indicator of Oocyte Developmental Potential</p><p>Markus Montag, Thomas Schimming, and Maria Köster</p><p>3. Morphological Assessment of Oocytes, Pronuclear and Cleavage Stage Embryos </p><p>Laura Rienzi, Benedetta Iussig, and Filippo Ubaldi</p><p>4. Morphological Assessment of Blastocyst Stage Embryos: Types of Grading Systems and Their Reported Outcomes</p><p>Basak Balaban and David K. Gardner</p><p>5. Real Time Imaging Strategies to Improve Morphological Assessment</p><p>María Cruz, Manuel Muñoz, and Marcos Meseguer</p><p>6. Limitations and Benefits of Morphologic Embryo Assessment Strategies: How Far Can Morphological Assessment Go in the Identification of Viable Embryos?</p><p>Denny Sakkas and David K. Gardner</p><p>7. Sperm Morphologic Characteristics and Their Impact on Embryo Quality and Pregnancy Outcome</p><p>Bhushan K. Gangrade and Ashok Agarwal</p><p>8. Objective Biomarkers of Sperm Development and Fertility: Assessment of Sperm-Zona Pellucida Binding Ability and Hyaluronic Acid Mediated Selection of Sperm for ICSI Fertilization </p><p>Gabor Huszar </p><p>9. Selecting the Best Sperm and Its Implications in Clinical Practice</p><p>Juan G. Alvarez</p><p>10. The Origins of Aneuploidy in Human Embryos</p><p>Elpida Fragouli and Joy Delhanty</p><p>11. Preimplantation Genetic Screening and Diagnosis Using Fluorescent In Situ Hybridization (FISH)</p><p>Tsilya Gerasimova and Maria D. Lalioti </p><p>12. Single Nucleotide Polymorphisms and Next Generation Sequencing</p><p>Alan H. Handyside and Dagan Wells</p><p>13. Use of Comparative Genomic Hybridization (CGH) and Microarray-CGH for Preimplantation Genetic Screening</p><p>Leeanda Wilton and Dagan Wells </p><p>14. Quantitative SNP Array and Real-Time PCR Based Human Preimplantation Embryo Aneuploidy Screening </p><p>Nathan R. Treff</p><p>15. Regulation of Gene Expression in the Oocyte and Early Embryo: Implications for Transcriptomic and Proteomic Embryo Assessment</p><p>Helena Kristiansson and Emre Seli</p><p>16. Transcriptomics Technology: Promise and Potential Pitfalls </p><p>Can Bruce and Asli Uyar</p><p>17. Transcriptomic Analysis of Cumulus and Granulosa Cells as a Marker of Embryo Viability</p><p>Elpida Fragouli  and Dagan Wells</p><p>18. Mass Spectrometry, Proteomics and the Study of Sperm Cell Biology</p><p>Mark A. Baker and R. John Aitken</p><p>19. Proteomic Analysis of Embryo Viability </p><p>Mandy G Katz-Jaffe and Susanna McReynolds</p><p>20. Metabolism of the Viable Human Embryo</p><p>David K. Gardner</p><p>21. Analysis of Respiration as an Indicator of Oocyte and Embryo Developmental Potential </p><p>David L. Keefe</p><p>22. Mitochondrial Activity as a Biomarker of Gamete and Embryo Health </p><p>Jonathan Van Blerkom</p><p>23. Carbohydrate Analysis and Embryo Viability</p><p>Michelle Lane and David K. Gardner</p><p>24. Identification of Viable Embryos by Non-invasive Measurement of Amino Acids in Culture Media</p><p>Franchesca D. Houghton</p><p>25. Metabolomic Profiling of Embryos Using Spectroscopy</p><p>Denny Sakkas and Emre Seli</p><p>26. Microfluidic Devices for the Analysis of Gamete and Embryo Physiology </p>George A. Thouas, David L. Potter, and David K. Gardner

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        Human Gametes and Preimplantation Embryos