What do we not bioenergetics? — A general view on the state of the art.- I: Bioenergetics of mitochondria: In vitro and in vivo studies.- Top-down elasticity analysis and its application to energy metabolism in isolated mitochondria and intact cells.- A model of O·2- generation in the complex III of the electron transport chain.- Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: Dependence upon both fluxes and forces.- Oxidative phosphorylation in intact hepatocytes: Quantitative characterization of the mechanisms of change in efficiency and cellular consequences.- Yeast mitochondrial metabolism: From in vitro to in situ quantitative study.- Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo.- Cytoskeleton and mitochondrial morphology and function.- Energetics of swelling in isolated hepatocytes: A comprehensive study.- II: Energy transfer networks: Molecular physiology of kinases, lessons from transgenic mice, mathematical theories.- Functional aspects of the X-ray structure of mitochondrial creatine kinase: A molecular physiology approach.- Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: Implications for cellular function and mitochondrial structure.- Molecular characterization of the creatine kinases and some historical perspectives.- Adenylate kinase: Kinetic behavior in intact cells indicates it is integral to multiple cellular processes.- Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies.- In situ measurements of creatine kinase flux by NMR. The lessons from bioengineered mice.- Mathematical model of compartmentalized energy transfer: Its use for analysis and interpretation of31P-NMR studies of isolated heart of creatine kinase deficient mice.- Functional coupling of creatine kinases in muscles: Species and tissue specificity.- Theoretical modelling of some spatial and temporal aspects of the mitochondrion/creatine kinase/myofibril system in muscle.- Quantitative studies of enzyme-substrate compartmentation, functional coupling and metabolic channelling in muscle cells.- III: Metabolic signalling and calcium: Regulation of mitochondrial oxidative phosphorylation in vivo.- Subtleties in control by metabolic channelling and enzyme organization.- The dynamic regulation of myocardial oxidative phosphorylation: Analysis of the response time of oxygen consumption.- Is it possible to predict any properties of oxidative phosphorylation in a theoretical way?.- Role of mitochondrial calcium transport in the control of substrate oxidation.- Modulation of cell calcium signals by mitochondria.- IV: Bioenergetics and medicine.- Mitochondrial function as a determinant of recovery or death in cell response to injury.- Role of cellular energetics in ischemia-reperfusion and ischemic preconditioning of myocardium.- Early ischemia-induced alterations of the outer mitochondrial membrane and the intermembrane space: A potential cause for altered energy transfer in cardiac muscle?.- Metabolic control analysis and mitochondrial pathologies.- Mechanisms of thyroid hormone control over sensitivity and maximal contractile responsiveness to ?-adrenergic agonists in atria.- Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: Down-regulation of the expression of creatine transporter isoforms in skeletal muscle.- Clinical cardiac magnetic resonance spectroscopy—present state and future directions.- Time-Resolved Spectroscopyof mitochondria, cells and tissues under normal and pathological conditions.- Index to Volume 184.
