Heart Hypertrophy and Failure

A. Genetic and Molecular Events.- 1. Molecular analysis of genotype/phenotype correlations of hypertrophic cardiomyopathy.- 2. Molecular genetics: New mutations that cause familial hypertrophic cardiomyopathy.- 3. Genetically determined cardiomyopathies in neuromuscular disease.- 4. Mitochondrial DNA mutations and heart failure.- 5. Mutations of myocardial mitochondrial DNA in diabetic patients.- 6. Differential screening and megasequencing of human heart cDNA library: A search for genes associated with heart failure.- 7. Intracellular signaling and genetic reprogramming during development of hypertrophy in cultured cardiomyocytes.- 8. Phenotypic changes in experimental cardiac hypertrophy and failure in relation to changes in heart rate variability.- 9. Relationship between myocardial function and expression of calcium cycling proteins in nonfailing and failing human myocardium.- 10. Cardiac remodeling by alterations in phospholamban protein levels.- 11. Regulation of sarcoplasmic reticulum gene expression during cardiac hypertrophy and heart failure.- 12. Hormonal regulation of cardiac sarcoplasmic reticulum Ca2+-ATPase expression.- B. Cellular and Biochemical Mechanisms.- 13. Growth of the neonatal pig heart.- 14. Regulation of cardiac myocyte differentiation, hyperplasia, and hypertrophy during normal and stressed fetal and neonatal growth.- 15. Rat heterotopic cardiac isograft model: What atrophy teaches us about hypertrophy.- 16. Myocardial cell abnormalities in heart failure: Experience from studies on single myocytes.- 17. Depression of sarcolemmal phospholipase C activity in congestive heart failure.- 18 Does decreased energy supply contribute to heart failure? The role of the creatine kinase system.- 19 Molecular basis for depressed contractile performance in human heart failure.- 20 Cellular adaptations in hypertrophy and heart failure.- 21 Progressive ventricular dilatation in heart failure: The role of myocardial collagenase.- 22 Interaction between cardiac myocytes and the extracellular matrix in failing human myocardium.- 23 Role of transforming growth factor beta1 in the remodeling of collagen matrix in the heart.- 24 Cytokines modulate the expression of specific proteins of the contractile apparatus in rat myocytes.- C. Signal Transduction Abnormalities.- 25 Rethinking ras: p21 ras proteins and cardiac signal transduction.- 26 Regulation of ?MHC gene expression by cAMP.- 27 Cardiac hypertrophy and the renin-angiotensin system.- 28 Stimulation of ?-adrenoceptor subtypes causes different effects in cardiac cells.- 29 Significance of adrenergic stimuli for cardiac remodeling under chronic overload: Relative importance of myocardial factors versus ventricular geometry in cardiac failure.- 30 Sympathetic neuroeffector mechanisms in the failing and hypertrophied myocardium.- 31. Status of post adrenergic receptor mechanisms in cardiac hypertrophy and heart failure.- 32. Role of protein kinase C in the development of non-insulin-dependent diabetic cardiomyopathy.- 33. The alteration of signal transduction system in heart failure: renin-angiotensin system in diseased human heart.- 34. Neuroendocrine mechanisms in the pathogenesis of heart failure.- 35. Neurohormonal responses in congestive heart failure: effect of ACE inhibitors in randomized controlled clinical trials.