The Tachykinin Receptors

I. Historical Perspectives of Tachykinins.- 1 History of Tachykinin Peptides 1.- 2 History of Tachykinin Receptors 23.- II. Characterization of Tachykinin Receptors.- 3 Biochemical Methods and Assays 39.- 4 Agonist and Antagonist Receptor Binding.- 5 Comparative Distribution of Receptor Types in the Mammalian Brain 101.- 6 Autoradiographic Localization of Receptors in Peripheral Tissues 125.- 7 Molecular Biology of Receptors: Structures, Expression,and Regulatory Mechanisms 165.- 8 Characterization of the NKl Receptor Using Photoaffinity Probes 219.- 9 Modeling of G-Protein-Coupled Receptors: Application to the NK1Tachykinin Receptor 237.- III. Mechanisms of Tachykinin Receptor Action.- 10 Receptors and the Inositol Phosphate—Calcium Signaling System 257.- 11 Signal Transduction Mechanisms of Tachykinin Effects on Ion Channels 285.- IV. Tachykinin Receptor Function.- 12 Structure—Activity Relationships of Agonist and Antagonist Ligands 329.- 13 Pharmacological Characterization of Receptor Types 367.- 14 Evidence for Receptor Subtypes/Species Variants of Receptors. 395.- 15 Role of Receptors in Nociception 471.- 16 Pharmacological Characterization of Receptors in the Spinal Cord of the Newborn Rat 499.- 17•Receptor Function in the Periphery 515.- 18 Receptor Involvement in Pathology and Disease 581.- V. Summary and Future Perspectives.- 19 Summary, Thoughts, and Future Perspectives 611.