Kathleen H. Goss,
Michael Kahn
Springer New York
2011e druk, 2011
9781441980229
Targeting the Wnt Pathway in Cancer
Specificaties
Gebonden, 240 blz.
|
Engels
Springer New York |
2011e druk, 2011
ISBN13: 9781441980229
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Specificaties
ISBN13:9781441980229
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:240
Uitgever:Springer New York
Druk:2011
Inhoudsopgave
<p>Chapter 1. An Introduction to Wnt Signaling </p><p>Paul Polakis </p><p> </p><p>Chapter 2. Regulation of Wnt Secretion and Distribution</p><p>Xiaofang Tang Xiaolan Fan and Xinhua Lin</p><p> </p><p>Chapter 3. Wnt Signaling in Stem Cells</p><p>Philipp C. Manegold, Jia-Ling and Teo Michael Kahn<sup><p>Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer</p><p>Masahiro Aoki and Makoto Mark Taketo</p><p> </p><p>Chapter 8. Targeting Wnt Signalling in Cancer</p><p>Aliaksei Holik and Alan R. Clarke</p><p>Cardiff School of Biosciences, Cardiff University,Cardiff, UK</p><p> </p><p>Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules </p><p>Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng</p><p> </p><p>Chapter 10. Targeting of Wnt Signaling Inside the Nucleus</p><p>Miki Shitashige and Tesshi Yamada</p><p></sup></p><p>Markus Müschen</p><p></p><p>Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer</p><p>Masahiro Aoki and Makoto Mark Taketo</p><p> </p><p>Chapter 8. Targeting Wnt Signalling in Cancer</p><p>Aliaksei Holik and Alan R. Clarke</p><p>Cardiff School of Biosciences, Cardiff University,Cardiff, UK</p><p> </p><p>Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules </p><p>Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng</p><p> </p><p>Chapter 10. Targeting of Wnt Signaling Inside the Nucleus</p><p>Miki Shitashige and Tesshi Yamada</p><p><p> </p><p>Chapter 4. Crosstalk of the Wnt Signaling Pathway</p><p>Michael Thompson, Kari Nejak-Bowen, Satdarshan P. S. Monga</p><p> </p><p>Chapter 5. Dysregulation of the WNT Pathway in Solid Tumors</p><p>Jenifer R. Prosperi, Hue H. Luu and Kathleen H. Goss</p><p> </p><p>Chapter 6. WNT/b-catenin Signaling in Leukemia</p><p>Markus Müschen</p><p></p><p>Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer</p><p>Masahiro Aoki and Makoto Mark Taketo</p><p> </p><p>Chapter 8. Targeting Wnt Signalling in Cancer</p><p>Aliaksei Holik and Alan R. Clarke</p><p>Cardiff School of Biosciences, Cardiff University,Cardiff, UK</p><p> </p><p>Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules </p><p>Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng</p><p> </p><p>Chapter 10. Targeting of Wnt Signaling Inside the Nucleus</p><p>Miki Shitashige and Tesshi Yamada</p><p>