A. Claudio Cuello
Springer New York
0e druk, 2010
9781441924469
Pharmacological Mechanisms in Alzheimer's Therapeutics
Specificaties
Paperback, 324 blz.
|
Engels
Springer New York |
0e druk, 2010
ISBN13: 9781441924469
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
The need for effective therapy to treat Alzheimer’s disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease. There is, however, a great deal of anticipation over the imminent development of effective therapies as a result of the identification of promising targets for drug development. This book investigates these targets and examines ongoing strategies to develop effective therapies for this devastating neurodegenerative condition.
Specificaties
ISBN13:9781441924469
Taal:Engels
Bindwijze:paperback
Aantal pagina's:324
Uitgever:Springer New York
Druk:0
Inhoudsopgave
Overview of the Alzheimer's Disease Pathology and Potential Therapeutic Targets.- Trial Designs and Outcomes to Monitor Novel Therapeutics in Alzheimer's Disease.- The Pharmacological Treatment of Alzheimer's Disease with Cholinesterase Inhibitors and Memantine.- M1 Muscarinic Agonists: A Comprehensive Therapy Against Major Hallmarks of Alzheimer's Disease.- Cholinergic Neurodegeneration in Alzheimer's Disease: Basis for Nerve Growth Factor Therapy.- The Rationale for Glutamatergic Therapy in Alzheimer's Disease.- Secretases as Pharmacological Targets in Alzheimer's Disease.- ?-Secretase as a Target for Alzheimer's Disease.- The Rationale for an Immunological Approach to Alzheimer's Therapeutics.- Neuroinflammation, Alzheimer Disease, and Other Aging Disorders.- Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Derived A?42-Lowering Molecules for Treatment and Prevention of Alzheimer's Disease (AD).- The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics.- Apolipoprotein E: A Potent Gene-Based Therapeutic Target for the Treatment of Sporadic Alzheimer's Disease.- Tau Pathology as a Target in Alzheimer's Therapeutics.- Design of Inhibitors of Amyloid-? Misfolding and Aggregation for Alzheimer's Therapy.- Potential Applications of Glycosaminoglycan-Related Compounds in Alzheimer's Disease.- Multifunctional Neuroprotective Drugs for the Treatment of Alzheimer's Disease.- Interpreting Clinical Studies of Putative Therapeutics for Alzheimer's Disease: The Case of Statins and NSAIDs.
