Dmitry I. Gabrilovich,
Arthur Andrew Hurwitz
Springer New York
2008e druk, 2010
9781441924001
Tumor-Induced Immune Suppression
Mechanisms and Therapeutic Reversal
Specificaties
Paperback, 302 blz.
|
Engels
Springer New York |
2008e druk, 2010
ISBN13: 9781441924001
Rubricering
Levertijd ongeveer 8 werkdagen
Samenvatting
There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in more or less cohesive structure and how they can help to improve immune response to tumors. This monograph will, for the first time, present a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It will discuss a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance.
Specificaties
ISBN13:9781441924001
Taal:Engels
Bindwijze:paperback
Aantal pagina's:302
Uitgever:Springer New York
Druk:2008
Inhoudsopgave
Immune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions.- Mechanisms of Tumor-Associated T-Cell Tolerance.- Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer.- Regulatory T Cells in Cancer.- Cancer-Induced Signaling Defects in Antitumor T Cells.- Immunobiology of Dendritic Cells in Cancer.- Macrophages and Tumor Development.- Myeloid-Derived Suppressor Cells in Cancer.- Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance.- Arginine Availability Regulates T-Cell Function in Cancer.- Protein–Glycan Interactions in the Regulation of Immune Cell Function in Cancer: Lessons from the Study of Galectins-1 and -3.- Role of Reactive Oxygen Species in T-Cell Defects in Cancer.- Tumor Stroma and the Antitumor Immune Response.