Chemistry of Bioconjugates – Synthesis, Characterization, and Biomedical Applications
Synthesis, Characterization, and Biomedical Applications
Samenvatting
Explores bioconjugate properties and applications of polymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine. With its emphasis on synthesis, properties and applications, this book enables readers to understand the connection between chemistry and the biological application of bioconjugated materials. Its detailed descriptions of methods make it possible for researchers to fabricate and take full advantage of bioconjugates for a broad range of applications. Moreover, the book sets the foundation for the development of new applications, including assays, imaging, biosensors, drug delivery, and diagnostics. Chemistry of Bioconjugates features contributions from an international team of leading experts and pioneers in the field. These contributions reflect the authors firsthand laboratory experience as well as a thorough review of the current literature. The books six sections examine: General methods of bioconjugation Polymer bioconjugates Organic nanoparticle–based bioconjugates Inorganic nanomaterial bioconjugates, including metals and metal oxides Cell–based, hydrogel/microgel, and glyco–bioconjugates Characterization, physico–(bio)chemical properties, and applications of bioconjugates This comprehensive exploration of bioconjugates includes discussions of polymers, dendrimers, lipids, nanoparticles, and nanotubes. References at the end of each chapter serve as a gateway to the most important original research findings and reviews in the field. By drawing together and analyzing all the latest chemical methods and research findings on the physico–chemical and biochemical properties of bioconjugates, Chemistry of Bioconjugates sheds new light on the significance and potential of bioconjugation. The book is recommended for organic and polymer chemists, biochemists, biomaterial scientists, carbohydrate chemists, biophysicists, bioengineers, and drug and gene delivery scientists.
Specificaties
Inhoudsopgave
<p>CONTRIBUTORS ix</p>
<p>SECTION I GENERAL METHODS OF BIOCONJUGATION</p>
<p>1 Covalent and Noncovalent Bioconjugation Strategies 3<br /> Rajesh Sunasee and Ravin Narain</p>
<p>SECTION II POLYMER BIOCONJUGATES</p>
<p>2 Bioconjugates Based on Poly(Ethylene Glycol)s and Polyglycerols 79<br /> Rajesh A. Shenoi, Fang Gao, Muhammad Imran ul–Haq, and Jayachandran N. Kizhakkedathu</p>
<p>3 Synthetic Polymer Bioconjugate Systems 104<br /> Marya Ahmed and Ravin Narain</p>
<p>4 Natural Polymer Bioconjugate Systems 133<br /> Lichao Liu, Xiuwei Pan, and Weian Zhang</p>
<p>5 Dendrimer Bioconjugates: Synthesis and Applications 146<br /> Ali Nazemi and Elizabeth R. Gillies</p>
<p>SECTION III ORGANIC NANOPARTICLES BASED BIOCONJUGATES</p>
<p>6 Bioconjugation Strategies: Lipids, Liposomes, Polymersomes, and Microbubbles 187<br /> Anirban Sen Gupta and Horst A. von Recum</p>
<p>7 Organic Nanoparticle Bioconjugate: Micelles, Cross–Linked Micelles, and Nanogels 203<br /> Maria Vamvakaki</p>
<p>8 Carbon Nanotubes and Fullerene C60 Bioconjugates 239<br /> Keshwaree Babooram and Ravin Narain</p>
<p>SECTION IV INORGANIC NANOMATERIALS BIOCONJUGATES (METALS, METAL OXIDES QUANTUM DOTS, IRON–OXIDE)</p>
<p>9 Gold Nanomaterials Bioconjugates 257<br /> Qian Yang</p>
<p>10 Methods for Magnetic Nanoparticle Synthesis and Functionalization 281<br /> Mohammad H. El–Dakdouki, Kheireddine El–Boubbou, Jingguang Xia, Herbert Kavunja, and Xuefei Huang</p>
<p>11 Quantum Dots Bioconjugates 315<br /> Xiaoze Jiang, Meifang Zhu, and Ravin Narain</p>
<p>12 Silica Nanoparticle Bioconjugates 327<br /> Yohei Kotsuchibashi, Mitsuhiro Ebara, and Ravin Narain</p>
<p>13 Polyhedral Oligomeric Silsesquioxanes (POSS) Bioconjugates 344<br /> Weian Zhang, Zhenghe Zhang, and Lizhi Hong</p>
<p>SECTION V CELL–BASED, HYDROGELS/MICROGELS AND GLYCO–BIOCONJUGATES</p>
<p>14 Cell–Based Bioconjugates 357<br /> Mitsuhiro Ebara</p>
<p>15 Bioresponsive Hydrogels and Microgels 370<br /> Xue Li and Michael J. Serpe</p>
<p>16 Conjugation Strategies Used for the Preparation of Carbohydrate–Conjugate Vaccines 387<br /> Rachel Hevey and Chang–Chun Ling</p>
<p>SECTION VI CHARACTERIZATION, PHYSICO–(BIO)CHEMICAL PROPERTIES, AND APPLICATIONS OF BIOCONJUGATES</p>
<p>17 Properties and Characterization of Bioconjugates 417<br /> Ali Faghihnejad, Jun Huang, and Hongbo Zeng</p>
<p>18 Physico–Chemical and Biochemical Properties of Bioconjugates 431<br /> Marya Ahmed and Ravin Narain</p>
<p>19 Applications of Bioconjugates 444<br /> Marya Ahmed and Ravin Narain</p>
<p>INDEX 457</p>