Immunotherapy in Translational Cancer Research
Samenvatting
A guide to state–of–the–art cancer immunotherapy in translational cancer research
A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer–fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues.
Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world s foremost cancer research and care center and:
Offers a comprehensive presentation of state–of–the–art cancer immunotherapy research that accelerates the pace of clinical cancer care
Filled with the concepts, examples, and approaches for developing individualized therapy
Explores the breath of treatments that reflect the complexity of the immune system itself
Includes contributions from a panel international experts in the field of immunotherapy
Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.
Specificaties
Inhoudsopgave
<p>Contributors, vii</p>
<p>Introduction, ix</p>
<p>1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer, 1<br />Saranya Chumsri and Keith L. Knutson</p>
<p>2 Monoclonal Antibody Therapy, 12<br />Elizabeth A. Mittendorf and Sabitha Prabhakaran</p>
<p>3 Somatic Mutations and Immunotherapy, 24<br />Eric Tran</p>
<p>4 Checkpoint Blockade, 37<br />Tracy A. Proverbs ]Singh, Jedd Wolchok, and Alexandra Snyder</p>
<p>5 Myeloid Leukemia Vaccines, 54<br />Paul M. Armistead and Jonathan S. Serody</p>
<p>6 Cancer Vaccines for Solid Tumors, 72<br />Timothy J. Vreeland, Garth S. Herbert, and George E. Peoples</p>
<p>7 Immunotherapy with Non Genetically Modified T Cells, 91<br />Cassian Yee</p>
<p>8 Immunotherapy with Genetically Modified T Cells, 101<br />Liora Schultz and Crystal Mackall</p>
<p>9 Immunomodulation with Adjuvants and Cytokines, 115<br />Dae won Kim and Adi Diab</p>
<p>10 Immune Cell Migration in Cancer and Immunotherapy, 132<br />Timothy Murray and Daniel E. Speiser</p>
<p>11 Repurposing of Drugs for Immunotherapy, 143<br />Jyothishmathi Swaminathan and Vidya Gopalakrishnan</p>
<p>12 Immunomodulation with Radiation, 161<br />Jonathan E. Schoenhals, Taylor R. Cushman, Alexandra P. Cadena, Sandra Demaria, and James W. Welsh</p>
<p>13 Good Manufacturing Practices Facilities for Cellular Therapy, 177<br />Andrew D. Fesnak and Bruce L. Levine</p>
<p>14 T Cell Receptor Mimic Antibodies, 186<br />Gheath Alatrash and Jeffrey J. Molldrem</p>
<p>15 Stem Cell Transplantation for Treatment of Malignancy, 201<br />Lohith S. Bachegowda and Richard E. Champlin</p>
<p>16 Natural Killer Cell Based Immunotherapy, 215<br />Jennifer A. Foltz, Jeffrey S. Miller, and Dean A. Lee</p>
<p>17 Immunologic Monitoring in Immuno ] Oncology, 228<br />William R. Gwin and Mary L. Disis</p>
<p>18 Cell ]Based Therapies for Canine Cancer, 252<br />Nicola J. Mason and M. Kazim Panjwani</p>
<p>19 Interaction between Targeted Therapy and Immunotherapy, 268<br />Peter A. Prieto, Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. Wargo</p>
<p>Index 286</p>