P Merino
John Wiley & Sons
e druk, 2013
9781118007518
Chemical Synthesis of Nucleoside Analogues
Specificaties
Gebonden, 912 blz.
|
Engels
John Wiley & Sons |
e druk, 2013
ISBN13: 9781118007518
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Chemical Synthesis of Nucleoside Analogues examines the application of synthetic methodologies to the preparation of compounds of biological interest, including the synthesis of nucleic acids on pre–existing nucleic acid templates, assembling RNA, or DNA. This comprehensive compendium culls expert contributions that highlight the structural components of nucleosides (supported by spectral data) and their modification as well as the synthetic strategies based on chemical approaches. The text serves undergraduate students, specialists, and researchers, allowing access to a variety of compounds without forgetting the biological importance of the target compounds.
Specificaties
Inhoudsopgave
<p>Contributors ix</p>
<p>Foreword xiii</p>
<p>Preface xv</p>
<p>1 Biocatalytic Methodologies for Selective Modified Nucleosides 1<br /> Miguel Ferrero, Susana Fern´andez, and Vicente Gotor</p>
<p>2 Nucleosides Modified at the Base Moiety 49<br /> O. Sari, V. Roy, and L. A. Agrofoglio</p>
<p>3 Chemical Synthesis of Acyclic Nucleosides 103<br /> Hai–Ming Guo, Shan Wu, Hong–Ying Niu, Ge Song, and Gui–Rong Qu</p>
<p>4 Phosphonated Nucleoside Analogues 163<br /> Roberto Romeo, Caterina Carnovale, Antonio Rescifina, and Maria Assunta Chiacchio</p>
<p>5 Chemical Syntheses of Nucleoside Triphosphates 209<br /> Lina Weinschenk and Chris Meier</p>
<p>6 Mononucleotide Prodrug Synthetic Strategies 229<br /> Suzanne Peyrottes and Christian P´erigaud</p>
<p>7 Synthesis of C–Nucleosides 263<br /> Omar Boutureira, M. Isabel Matheu, Yolanda D´ýaz, and Sergio Castill´on</p>
<p>8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance 317<br /> Maurice Okello and Vasu Nair</p>
<p>9 Synthesis of Conformationally Constrained Nucleoside Analogues 345<br /> Esma Maougal, Jean–Marc Escudier, Christophe Len, Didier Dubreuil, and Jacques Lebreton</p>
<p>10 Synthesis of 3–Spiro–Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives 427<br /> Mar´ýa–Jos´e Camarasa, Sonsoles Vel´azquez, Ana San–F´elix, and Mar´ýa–Jes´us P´erez–P´erez</p>
<p>11 l–Nucleosides 473<br /> Daniela Perrone and Massimo L. Capobianco</p>
<p>12 Chemical Synthesis of Carbocyclic Analogues of Nucleosides 535<br /> E. Leclerc</p>
<p>13 Uncommon Three–, Four–, and Six–Membered Nucleosides 605<br /> E. Groaz and P. Herdewijn</p>
<p>14 Recent Advances in Synthesis and Biological Activity of 4–Thionucleosides 655<br /> Varughese A. Mulamoottil, Mahesh S. Majik, Girish Chandra, and Lak Shin Jeong</p>
<p>15 Recent Advances in the Chemical Synthesis of Aza–Nucleosides 699<br /> Tom´as Tejero, Ignacio Delso, and Pedro Merino</p>
<p>16 Stereoselective Methods in the Synthesis of Bioactive Oxathiolane and Dioxolane Nucleosides 727<br /> D. D Alonzo and A. Guaragna</p>
<p>17 Isoxazolidinyl Nucleosides 781<br /> Ugo Chiacchio, Antonino Corsaro, Salvatore Giofr`e, and Giovanni Romeo</p>
<p>18 Synthetic Studies on Antifungal Peptidyl Nucleoside Antibiotics 819<br /> Apurba Datta</p>
<p>19 Chemical Synthesis of Conformationally Constrained PNA Monomers 847<br /> Pedro Merino and Rosa Matute</p>
<p>Index 881</p>
<p>Foreword xiii</p>
<p>Preface xv</p>
<p>1 Biocatalytic Methodologies for Selective Modified Nucleosides 1<br /> Miguel Ferrero, Susana Fern´andez, and Vicente Gotor</p>
<p>2 Nucleosides Modified at the Base Moiety 49<br /> O. Sari, V. Roy, and L. A. Agrofoglio</p>
<p>3 Chemical Synthesis of Acyclic Nucleosides 103<br /> Hai–Ming Guo, Shan Wu, Hong–Ying Niu, Ge Song, and Gui–Rong Qu</p>
<p>4 Phosphonated Nucleoside Analogues 163<br /> Roberto Romeo, Caterina Carnovale, Antonio Rescifina, and Maria Assunta Chiacchio</p>
<p>5 Chemical Syntheses of Nucleoside Triphosphates 209<br /> Lina Weinschenk and Chris Meier</p>
<p>6 Mononucleotide Prodrug Synthetic Strategies 229<br /> Suzanne Peyrottes and Christian P´erigaud</p>
<p>7 Synthesis of C–Nucleosides 263<br /> Omar Boutureira, M. Isabel Matheu, Yolanda D´ýaz, and Sergio Castill´on</p>
<p>8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance 317<br /> Maurice Okello and Vasu Nair</p>
<p>9 Synthesis of Conformationally Constrained Nucleoside Analogues 345<br /> Esma Maougal, Jean–Marc Escudier, Christophe Len, Didier Dubreuil, and Jacques Lebreton</p>
<p>10 Synthesis of 3–Spiro–Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives 427<br /> Mar´ýa–Jos´e Camarasa, Sonsoles Vel´azquez, Ana San–F´elix, and Mar´ýa–Jes´us P´erez–P´erez</p>
<p>11 l–Nucleosides 473<br /> Daniela Perrone and Massimo L. Capobianco</p>
<p>12 Chemical Synthesis of Carbocyclic Analogues of Nucleosides 535<br /> E. Leclerc</p>
<p>13 Uncommon Three–, Four–, and Six–Membered Nucleosides 605<br /> E. Groaz and P. Herdewijn</p>
<p>14 Recent Advances in Synthesis and Biological Activity of 4–Thionucleosides 655<br /> Varughese A. Mulamoottil, Mahesh S. Majik, Girish Chandra, and Lak Shin Jeong</p>
<p>15 Recent Advances in the Chemical Synthesis of Aza–Nucleosides 699<br /> Tom´as Tejero, Ignacio Delso, and Pedro Merino</p>
<p>16 Stereoselective Methods in the Synthesis of Bioactive Oxathiolane and Dioxolane Nucleosides 727<br /> D. D Alonzo and A. Guaragna</p>
<p>17 Isoxazolidinyl Nucleosides 781<br /> Ugo Chiacchio, Antonino Corsaro, Salvatore Giofr`e, and Giovanni Romeo</p>
<p>18 Synthetic Studies on Antifungal Peptidyl Nucleoside Antibiotics 819<br /> Apurba Datta</p>
<p>19 Chemical Synthesis of Conformationally Constrained PNA Monomers 847<br /> Pedro Merino and Rosa Matute</p>
<p>Index 881</p>
