Leukemia and Lymphoma
Detection of Minimal Residual Disease
Samenvatting
In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.
Specificaties
Inhoudsopgave
Richard Ratei and Wolf-Dieter Ludwig
Flow-Cytometry-Based Studies of Minimal Residual Disease in Children with Acute Lymphoblastic Leukemia
Dario Campana
PCR Methods for the Detection of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia
Geoffrey Neale
Statistical Considerations in the Analysis of Minimal Residual Disease
Dennis A. Johnston and Theodore F. Zipf
The Application of Minimal Residual Disease Detection Methodology to the Clinical Decision-Making Process
Theodore F. Zipf and Dennis A. Johnston
Measurement of Minimal Residual Disease in Children Undergoing Allogeneic Stem Cell Transplant for Acute Lymphoblastic Leukemia
John Moppett, Amos Burke, Christopher Knechtli, Anthony Oakhill, Colin Steward, and Nicholas J. Goulden
Molecular Investigation of Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia of B Lineage
Letizia Foroni, Forida Y. Mortuza, and A. Victor Hoffbrand
Investigation of Minimal Residual Disease in Acute Myeloid Leukemia by Immunophenotyping
Jesús F. San Miguel, María B. Vidriales, and Alberto Orfao
Minimal Residual Disease in Acute Myeloid Leukemia: RT-PCR-Based Studies of Fusion Transcripts
Guido Marcucci and Michael A. Caligiuri
Minimal Residual Disease in Acute Promyelocytic Leukemia
Francesco Lo Coco and Daniela Diverio
Minimal Residual Disease in Chronic Myelogenous Leukemia: Results of RT-PCR Detection of BCR-ABL Transcripts
Nicholas C. P. Cross and Andreas Hochhaus
Utility of PCR Assessment of Minimal Residual Disease After Stem Cell Transplantation in Non-Hodgkin's Lymphoma
Angela M. Krackhardt and John G. Gribben
Real-Time Polymerase Chain Reaction of Genomic DNA for Quantitation of t(14;18)
Apostolia-Marie Tsimberidou, Yunfang Jiang, Richard J.Ford, Fernando Cabanillas, and Andreas H. Sarris
Monitoring Follicular Lymphoma by Polymerase Chain Reaction
Ming-Sheng Lee and Fernando Cabanillas
Editors' Notes
Index