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Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics

Specificaties
Paperback, blz. | Engels
Elsevier Science | e druk, 2024
ISBN13: 9780443288746
Rubricering
Elsevier Science e druk, 2024 9780443288746
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

“Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics” provides a comprehensive overview and update of the mass-action law-based unified dose-effect biodynamics, pharmacodynamics, bioinformatics, and the combination index theorem for synergy definition (MAL-BD/PD/BI/CI). Contents advocate the fundamental MAL-PD/BI/CI/BI principle for biomedical R&D, clinical trials protocol design computerized data analysis, illustrates the MAL-dynamics theory with sample analysis, and includes data entry and automated computer report print-outs. In 11 sections “Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics” leads the reader from an introduction and overview, to trial protocols and MAL-PD/CI approach for biomedical R&D in vitro and in animals. It describes the current Landscape of International FDA Drug Evaluation, Clinical Pharmacology, and Clinical Trials Guidance. This is a valuable resource for biomedical researchers, healthcare professionals, and students seeking to harness the power of data informatics in precision medicine.

Specificaties

ISBN13:9780443288746
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

1. A new alternative concept for cost-effective R&D: The MALdynamics/algorithms/digital informatics<br>2. General dynamics principle for experimental design of all dose-effect analysis and computer simulation<br>3. MAL-PD/CI approach for biomedical R&D in vitro and in animals<br>4. Implementation for MAL-PD Econo-Green R&D<br>5. Digital R&D approach to international FDA drug evaluation, clinical pharmacology, and clinical trial guidance<br>6. The epothilone story: Experimental success and clinical failure<br>7. MAL-PD Advocacy: Public hearing, public comments and scientific recommendations<br>8. Consensus for international FDAs on definitions of &ldquo;MAL-PD&rdquo; and &ldquo;Synergism&rdquo;<br>9. Historical, philosophical, and mathematical analysis: Why the MAL-PD approach and the traditional approach are opposite yet complementary<br>10. Multidisciplinary examples of applications: Papers using the MAL-PD/BD/CI/BI theory/method<br>11. Concluding remarks

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        Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics