Cell and Gene Therapies for Neurologic Diseases
Specificaties
Gebonden, blz.
|
Engels
Elsevier Science |
e druk, 2024
ISBN13: 9780323901208
Rubricering
Onderdeel van serie
Handbook of Clinical Neurology
Levertijd ongeveer 8 werkdagen
Samenvatting
Cell and Gene Therapies for Neurologic Diseases, Volume 205 comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson’s, Huntington’s, ALS, stroke, spinal cord RP, demyelination, and epilepsy. As the emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders, and is now ready to do so for neurological diseases, these therapeutic modalities currently complement, and may in time, supplant small molecule drugs.
Specificaties
Inhoudsopgave
Section 1. Cellular Therapies<br>1. Introduction to stem cell biology and its role in treating neurologic disorders<br>2. History of cellular grafting for CNS repair - A clinical perspective<br>3. Autologous vs. heterologous cell replacement strategies for Parkinson disease and other neurologic diseases<br><br>Section 2. Gene therapies<br>4. Viral vectors and gene delivery to the central nervous system<br>5. Viral versus Non-viral approaches<br><br>Section 3. General Considerations (for cell and gene therapies)<br>6. Clinical/surgical considerations<br>7. Ethics of gene and cell therapy development for neurological disorders<br>8. Clinical trial designs and endpoints<br>9. Immunology of such therapies<br>10. Scaling of cell and gene therapies to population<br>11. The Health economics of cell and gene therapies<br><br>Section 4. Disease specific interventions using cells and genes<br>12. Disease specific interventions: The use of cell and gene therapies for Parkinson disease<br>13. Using gene or cell therapies to treat Huntington’s disease<br>14. Disorders of the motorneuron including ALS and SMA<br>15. Gene and cell-based therapies for retinal and optic nerve disease<br>16. Disease specific interventions using cell therapies for spinal cord disease/injury<br>17. Stem and progenitor cell-based therapy of myelin disorders<br>18. Cell and gene therapy in neuro-oncology