<p>PART I: INTRODUCTION<br>1 Sepsis: Past, Present, and Futured Lessons From COVID-19<br>José-Artur Paiva and Jordi Rello<br>2 Sepsis Definitions: A Historical Perspective<br>Javier Perez-Fernandez, Arlene C. Torres, and Paola Perez<br>3 The Epidemiology of Sepsis<br>Jamila Hedjal<br>PART II: BASIC CONCEPTS<br>4 Sepsis Pathophysiology<br>Maria Jimena Aleman, Luisa Cruz, Jorge Hidalgo, and Allyson Hidalgo<br>5 Sepsis and Microcirculation<br>Carlos Enrique A. Orellana Jimenez<br>6 Genetics and Sepsis<br>Gabriela Alvarado<br>PART III: DIAGNOSIS AND MONITORING<br>7 Early Detection and Screening<br>Márcio Borges Sá and Rafael Zaragoza Crespo<br>8 Diagnosis and Monitoring of Sepsis<br>Pietro Arina and Mervyn Singer<br>9 Sepsis: Molecular Diagnostics and Biomarkers<br>John Lyons and Craig Coopersmith<br>10 Hemodynamic Monitoring: Current Practice and New Perspectives<br>Christopher Lai and Jean-Louis Teboul<br>11 Point of Care Ultrasound in the Management of Sepsis<br>Saad Mahdy, Ahmed F. Hegazy and Tharawt Aisa<br>12 New Approaches and Understanding of Sepsis<br>Vanessa Fonseca-Ferrer, Sulimar Morales-Colón, Luis Gerena-Montano, William<br>Rodríguez-Cintrón, and Gloria M. Rodríguez-Vega<br>13 Sepsis Quality Indicators in the Emergency Department<br>Luis Antonio Gorordo-Delsol and Graciela Merinos-Sánchez<br>PART IV: TREATMENT<br>14 Sepsis Treatment: Fluids<br>Michaël Mekeirele, Domien Vanhonacker and Manu L.N.G. Malbrain<br>15 Vasopressor Therapy in Septic Shock<br>Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed and Ahsina Jahan Lopa<br>16 Mechanical Ventilation in Sepsis<br>Carlos Sánchez, Orlando Pérez-Nieto and Eder Zamarrón<br>17 Extracorporeal Membrane Oxygenation for the Support of Patients With Refractory Septic Shock<br>Jose Alfonso Rubio Mateo-Sidron<br>18 Antimicrobials in the Management of Sepsis<br>Judith Jacobi<br>19 Kidney Support in Sepsis<br>Javier Maynar, Helena Barrasa, Alex Martin and Fernando Fonseca<br>20 Hematological Support in Sepsis<br>Zulmi Aranda, Gerhaldine Morazan and Allyson Hidalgo<br>21 Specific Treatment of Focus Control in Sepsis<br>Xavier Guirao, Montserrat Juvany, Clara Centeno and Josep Maria Badia<br>22 Sepsis Adjunctive Therapies<br>Javier Perez-Fernandez and Paola Perez<br>23 Glycemic Control and Stress Ulcer Prophylaxis<br>Janice L. Zimmerman<br>24 Nutrition in Sepsis<br>Victor Sanchez Nava</p> <p>PART V: SPECIAL SETTINGS<br>25 Fever in Intensive Care Units<br>Kazuaki Atagi<br>26 Sepsis--In the Era of Antimicrobial Resistance<br>Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed and Ahsina Jahan Lopa<br>27 Factors Underlying Racial and Gender Disparities in Sepsis Management<br>Ryoung-Eun Ko and Gee Young Suh<br>28 Sepsis in Special Populations<br>Marie Baldisseri, Laura S. Johnson, Michael Mazzei and Mary Jane Reed<br>29 Comprehensive Management of Sepsis in Pediatrics<br>Elisabeth Esteban, Juan Carlos de Carlos, Juan Ignacio Sánchez and Javier Gil Anton<br>30 Maternal Sepsis<br>Luis Antonio Gorordo-Delsol, Graciela Merinos- Sánchez, Lucina Nieves-Torres and Jeanette Zúñiga Escorza<br>PART VI: SPECIAL CONSIDERATIONS<br>31 Role of Preventive Measures in Sepsis<br>Jorge Sinclair, Jorge E. Sinclair De Frías and Lorenzo Olivero<br>32 Value of the Protocolization and Sepsis Performance Improvement Program in Early Identification<br>Carlos Sanchez<br>33 Long-Term Sequelae of Sepsis<br>Ahmed Taha<br>PART VII: FUTURE OUTLOOK<br>34 New Diagnostic and Therapeutic Perspectives<br>Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Erika-Paola Plata Menchaca and Ricard Ferrer<br>35 Artificial Intelligence in Sepsis<br>Michiel Schinkel, Ketan Paranjape, Prabath W.B. Nanayakkara and W. Joost Wiersinga<br></p>
