<p>Preface</p> <p>Gerald Litwack</p> <p>1. Aging and the hypothalamic-pituitary-thyroid axis</p> <p>Leonidas H. Duntas</p> <p>2. Hypothalamic aging and hormones</p> <p>Zi-Jian Cai</p> <p>3. Hypothalamic gene transfer of BDNF promotes healthy aging</p> <p>Lei Cao, Seemaab Ali and Nicholas J. Queen</p> <p>4. Melatonin and healthy aging</p> <p>Daniel P. Cardinali</p> <p>5. Luteinizing hormone and the aging brain</p> <p>Megan Mey, Sabina Bhatta and Gemma Casadesus</p> <p>6. Leptin regulation of hippocampal synaptic function in health and disease</p> <p>Kirsty Hamilton and Jenni Harvey</p> <p>7. Endocannabinoids and aging—Inflammation, neuroplasticity, mood and pain</p> <p>Yongsoon Park and Bruce A. Watkins</p> <p>8. Parathyroid hormone levels and aging: Effect on balance</p> <p>Lavanya Murthy and Gustavo Duque</p> <p>9. Insulin and aging</p> <p>Mirian Ayumi Kurauti, Gabriela Moreira Soares, Carine Marmentini, Gabriela Alves Bronczek, Renato Chaves Souto Branco and Antonio Carlos Boschero</p> <p>10. Sirtuins and the prevention of immunosenescence</p> <p>Denise Lasigliè</p> <p>11. Alterations in cyclic nucleotide signaling are implicated in healthy aging and age-related pathologies of the brain</p> <p>Nicole Gorny and Michy P. Kelly</p> <p>12. Aging and FGF23-klotho system</p> <p>Makoto Kuro-O</p> <p>13. Aging and sex hormones in males</p> <p>Maria Chiara Decaroli, Sara De Vincenti and Vincenzo Rochira</p> <p>14. Sexual dimorphism, aging and immunity</p> <p>Veena Taneja</p> <p>15. Hormones and bone loss across the menopause transition</p> <p>Arun S. Karlamangla, Albert Shieh and Gail A. Greendale</p> <p>16. Relaxin abrogates genomic remodeling of the aged heart</p> <p>Guillermo Romero and Guy Salama</p> <p>17. Role of FoxO transcription factors in aging-associated cardiovascular diseases</p> <p>Sneha Mishra, Venkatraman Ravi and Nagalingam Ravi Sundaresan</p> <p>18. Ghrelin and adipokines: An overview of their physiological role, antimicrobial activity and impact on cardiovascular conditions</p> <p>Luís Perpétuo, Pierre Marie Voisin, Francisco Amado, Christophe Hirtz and Rui Vitorino</p> <p>19. Sex hormones and cognition in aging</p> <p>Caroline Gurvich, Jessica Le, Natalie Thomas, Elizabeth H. X. Thomas and Jayashri Kulkarni</p> <p>20. Role of hormones in sarcopenia</p> <p>Priego T, Martín AI, González-Hedström D, Granado M, López-Calderón A and Daniel Cardalini</p> <p>21. Sources of lumbar back pain during aging and potential therapeutic targets</p> <p>T. Peter Li, Amit Jain and Xu Cao</p> <p>22. Leydig cell aging: Molecular mechanisms and treatments</p> <p>V. Papadopoulos and B. Zirkin</p> <p>23. Adiponectin/AdipoRs signaling as a key player in testicular aging and associated-metabolic disorders</p> <p>Mayank Choubey, Ashutosh Ranjan and Amitabh Krishna</p>