SECTION 1 Mechanisms of Drug Action and Therapeutic Principles<br>1. Introduction<br>2. Cellular Receptors and Drug Concentration-Response Relationships<br>3. Pharmacokinetics<br>4. Pharmacogenetics<br>5. Drug Discovery, Development, and Regulation<br><br>SECTION 2 Chemical Mediators and Drugs Affecting Autonomic and Neuromuscular Synapses<br>6. Introduction to the Autonomic Nervous System<br>Cholinergic Drugs<br>7. Muscarinic Agonists, Cholinesterase Inhibitors, and Their Clinical Uses<br>8. Muscarinic Antagonists and Their Clinical Uses<br>9. Nicotinic Agonists and Their Clinical Uses<br>10. Neuromuscular Blocking Drugs and Nicotinic Antagonists<br>Adrenergic Drugs<br>11. Adrenergic Agonists and Their Clinical Uses<br>12. Adrenergic Antagonists and Their Clinical Uses<br><br>SECTION 3 Drug Treatment for Disorders Affecting the Central Nervous System<br>13. The Central Nervous System<br>14. Drug Therapy for Alzheimer Disease and Other Cognitive Disorders/Dementias<br>15. Pharmacotherapy of Basal Ganglia Disorders: Parkinson Disease and Huntington Disease<br>16. Drug Therapy for Psychoses and Bipolar Disorder<br>17. Drug Therapy for Depression and Anxiety<br>18. Drug Therapy for the Management of Attention Deficit-Hyperactivity Disorder<br>19. Drug Therapy for Insomnia and the Hypersomnias<br>20. Drug Therapy for Managing Obesity and Eating Disorders<br>21. Treatment of Seizure Disorders<br>22. Drug Therapy for Spasticity Disorders<br>23. Ethanol, Other Alcohols, and Medications for Alcohol Use Disorder<br>24. Psychoactive Compounds and Substance Use Disorder<br><br>SECTION 4 Drug Therapy for Pain Management<br>25. Introduction<br>26. General Anesthetics<br>27. Local Anesthetics<br>28. Opioid Analgesics<br>29. Nonsteroidal Antiinflammatory Drugs and Acetaminophen<br>30. Cannabinoids<br>31. Drug Therapy for Migraine Headache<br><br>SECTION 5 Treatment of Inflammatory, Allergic and Immunologic Disorders<br>32. Drug Therapy for Gout and Hyperuricemia<br>33. Pharmacological Interventions for Allergic Reactions<br>34. Immunosuppressants for Autoimmune Disorders and Organ Transplantation<br>35. Drug Therapy for Rheumatoid Arthritis<br><br>SECTION 6 Drug Treatment for Cardiovascular Diseases<br>36. Introduction to the Regulation of Cardiovascular Function<br>37. Overview of Hypertension Management and Drugs That Decrease Sympathetic Tone<br>38. Diuretics and Drugs That Affect Volume and Electrolyte Content<br>39. Drugs Affecting the Renin-Angiotensin-Aldosterone System<br>40. Calcium-Channel Blockers<br>41. Vasodilators for Hypertensive Crises, Pulmonary Hypertension, and Erectile Dysfunction<br>42. Treatment of Hyperlipidemias and Atherosclerotic Cardiovascular Disease<br>43. Treatment of Myocardial Ischemia and Angina Pectoris<br>44. Treatment of Heart Failure<br>45. Antiarrhythmic Drugs<br>46. Anticoagulant, Antiplatelet, and Fibrinolytic Medications<br>47. Drug Therapy for Hemophilia and the Deficiency Anemias<br><br>SECTION 7 Treatment of Endocrine Disorders<br>48. Introduction to Endocrine Pharmacology<br>49. Treatment of Hypothalamic and Pituitary Disorders<br>50. Diagnosis and Treatment of Adrenocorticosteroid Disorders<br>51. Female Hormone Regulation<br>52. Androgens, Antiandrogens, and Their Clinical Uses<br>53. Drug Therapy for the Management of Diabetes<br>54. Drug Therapy for the Management of Thyroid Disorders<br>55. Calcium Regulating Hormones and Other Agents Affecting Bone<br><br>SECTION 8 Chemotherapy <br>Infectious Diseases<br>56. Principles of Antimicrobial Use<br>57. Drugs Targeting Bacterial Cell Walls and Membranes<br>58. Drugs Targeting Bacterial Protein Synthesis<br>59. Drugs Targeting Bacterial DNA<br>60. Antimycobacterial Agents<br>61. Drugs Targeting Resistant Organisms<br>Parasitic Diseases<br>62. Antifungal Agents<br>63. Antimalarial and Other Antiprotozoal Agents<br>64. Anthelmintics and Ectoparasiticides<br>Viruses<br>65. Antiviral Agents<br>66. Antiretroviral Drugs for HIV<br>Cancer<br>67. Principles of Cancer and Antineoplastic Drug Use<br>68. Cytotoxic Agents<br>69. Targeted Anticancer Agents<br>70. Immunological and Cell-Based Therapies<br><br>SECTION 9 Special Considerations<br>71. Therapeutic Use of Hematopoietic Growth Factors<br>72. Gastrointestinal Disorders and Their Treatment<br>73. Pharmacological Interventions for Asthma and Chronic Obstructive Pulmonary Disorders<br>74. Dietary Supplements, Nutraceuticals, and Natural Products<br>75. Essentials of Toxicology<br>76. Therapeutic Considerations for Pregnant, Pediatric, Geriatric, and Obese Individuals<br>Hypersomnias