Section 1 STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION<br>1. Voltage-gated sodium channels and electrical excitability of the heart<br>2. Voltage-gated calcium<br>3. Voltage-gated potassium channels<br>4. Structural and molecular bases of cardiac inward rectifier potassium channel function<br>5. Mammalian calcium pumps in health and disease<br>6. Structural and molecular bases of sarcoplasmic reticulum ion channel function<br>7. Organellar ion channels and transporters<br>8. Molecular organization, gating, and function of connexin-based gap junction channels and hemichannels<br><br>Section 2 BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION<br>9. Structure-function relations of heterotrimetric complexes of sodium channel a and β subunits<br>10. Regulation of cardiac calcium channels<br>11. Inhibition of phosphoinositide 3-kinase and acquired long QT syndrome<br>12. Structural determinants and biophysical properties of hERG1 channel gating<br>13. Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents<br>14. Cardiac stretch-activated channels and mechano-electric coupling<br>15. Biophysical properties of gap junctions<br>16. Excitation-contraction coupling<br><br>Section 3 INTERMOLECULAR INTERACTIONS AND CARDIOMYOCYTE ELECTRICAL FUNCTION<br>17. Ion channel trafficking in the heart<br>18. Microdomain interactions of macromolecular complexes and regulation of the sodium channel nav1.5<br>19. Fibroblast growth factor homologous factors modulate cardiac calcium channels<br>20. Macromolecular complexes and cardiac potassium channels<br>21. Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias<br>22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitability<br>23. Function and dysfunction of ion channel membrane trafficking and post translational modification<br>24. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling<br><br>Section 4 CELL BIOLOGY OF CARDIAC IMPULSE INITIATION AND PROPAGATION<br>25. Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: Insights from sinoatrial node development and function<br>26. Gene therapy and biologic pacing<br>27. Intercellular communication and impulse propagation<br>28. Mechanisms of normal and dysfunctional sinoatrial nodal excitability and propagation<br>29. Cell biology of the specialized cardiac conduction system<br>30. Cardiac remodeling and regeneration<br><br>Section 5 MODELS OF CARDIAC EXCITATION<br>31. Ionic mechanisms of atrial action potentials<br>32. Genetic algorithms to generate dynamical complexity electrophysiological models<br>33. Calcium signaling in cardiomyocyte dodels with realistic geometries<br>34. Theory of rotors and arrhythmias<br>35. Computational approaches for accurate rotor localization in the human atria<br>36. Modeling the aging heart<br><br>Section 6 NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY<br>37. Innervation of the sinoatrial node<br>38. Mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.<br>39. Pulmonary vein ganglia and the neural regulation of the heart rate<br>40. Neural activity and atrial tachyarrhythmias<br>41. Sympathetic innervation and cardiac arrhythmias<br><br>Section 7 ARRHYTHMIA MECHANISMS<br>42. The molecular pathophysiology of atrial fibrillation<br>43. Myofibroblasts, cytokines, and persistent atrial fibrillation<br>44. Role of the autonomic nervous system in atrial fibrillation<br>45. Rotors in human atrial fibrillation<br>46. Body surface frequency-phase mapping of atrial fibrillation<br>47. Panoramic mapping of atrial fibrillation from the body surface<br>48. Mechanisms of human ventricular tachycardia and human ventricular fibrillation<br>49. Genetics of atrial fibrillation<br><br>Section 8 MOLECULAR GENETICS AND PHARMACOGENOMICS<br>50. Mechanisms in heritable sodium channel diseases<br>51. Genetic, ionic, and cellular mechanisms underlying the J-wave syndromes<br>52. Inheritable potassium channel diseases<br>53. Inheritable phenotypes associated with altered intracellular calcium regulation<br><br>Section 9 PHARMACOLOGIC, GENETIC, AND CELL THERAPY OF ION CHANNEL DYSFUNCTION<br>54. Pharmacologic bases of antiarrhythmic therapy<br>55. Pharmacogenomics of cardiac arrhythmias<br>56. Gene therapy to treat cardiac arrhythmias<br>57. Highly mature human iPSC-derived cardiomyocytes as models for cardiac electrophysiology and drug testing<br>58. Cardiac repair with human induced pluripotent stem cell-derived cardiovascular cells.<br><br>Section 10 DIAGNOSTIC EVALUATION<br>59. Assessment of the patient with a cardiac arrhythmia<br>60. Electrocardiography of tachyarrhythmias: Differential diagnosis of narrow and wide QRS complex tachycardias<br>61. Electroanatomic mapping for arrhythmias<br>62. Computed tomography for electrophysiology<br>63. Magnetic resonance imaging for electrophysiology<br>64. Intracardiac echocardiography for electrophysiology<br>65. Exercise-induced arrhythmias<br>66. Cardiac monitoring: short- and long-term recording<br>67. Head-up tilt table testing<br>68. Autonomic regulation and cardiac risk<br>69. T-wave alternans<br>70. Noninvasive electrocardiographic imaging of human ventricular arrhythmias and Electrophysiological Substrate<br>71. Genetic testing<br><br>Section 11 SUPRAVENTRICULAR TACHYARRHYTHIAS: MECHANISMS, CLINICAL FEATURES, AND MANAGEMENT<br>72. Sinus node abnormalities<br>73. Atrial tachycardia<br>74. Atrial tachycardia in adults with congenital heart disease<br>75. Typical and atypical atrial flutter: Mapping and ablation<br>76. Atrial fibrillation<br>77. Preexcitation, atrioventricular reentry, variants<br>78. Electrophysiological characteristics of atrioventricular nodal reentrant tachycardia: Implications for the rentrant circuits<br>79. Junctional tachycardia<br><br>Section 12 VENTRICULAR TACHYCARRHYTHMIAS: MECHANISMS, CLNICAL FEATURES, AND MANAGEMENT<br>80. Premature ventricular complexes<br>81. Outflow tract ventricular tachycardias: Mechanisms, clinical features, and management<br>82. Fascicular ventricular arrhythmias<br>83. Bundle branch reentry tachycardia<br>84. Ischemic heart disease<br>85. Ventricular tachycardia in patients with dilated cardiomyopathy<br>86. Ventricular arrhythmias in hypertrophic cardiomyopathy<br>87. Ventricular tachycardias in arrhythmogenic right ventricular dysplasia/cardiomyopathy<br>88. VTs in catcholaminergic cardiomyopathy (catecholaminergic polymorphic ventricular tachycardia)<br>89. Ventricular arrhythmias in heart failure<br>90. Arrhythmias and conduction disturbances in non-compaction cardiomyopathy<br>91. Takotsubo cardiomyopathy<br>92. Brugada syndrome<br>93. Long and short QT syndromes<br>94. Anderson-Tawil syndrome<br>95. Timothy syndrome<br>96. J-wave syndromes<br>97. Idiopathic ventricular fibrillation<br>98. Sudden infant death syndrome<br>99. Sudden cardiac arrest/death in adults<br>100. Neurologic disorders<br>101. Drug-induced ventricular tachycardia<br>102. Ventricular arrhythmias in congenital heart disease<br><br>Section 13 SYNCOPE AND BRADYARRHYTHMIAS<br>103. Syncope<br>104. Postural orthostatic tachycardia syndrome<br>105. Progressive conduction system disease<br>106. Atrioventricular block<br><br>Section 14 ARRHYTHMIAS IN SPECIAL POPULATIONS PHARMACOLOGIC THERAPY<br>107. Sex differences in arrhythmias<br>108. Sudden cardiac death in athletes, including commotio cordis<br>109. Pediatric populations<br>110. Sleep-disordered breathing and arrhythmias<br>111. Ventricular assist devices and cardiac transplantation recipients<br><br>Section 15 PHARMACOLOGIC THERAPY<br>112. Standard antiarrhythmic drugs<br>113. Innovations in antiarrhythmic drug therapy<br>114. Nontraditional drugs for sudden cardiac death<br>115. Prevention of stroke in atrial fibrillation: warfarin, anti-factor Xa and thrombin drugs<br><br>Section 16 CARDIAC IMPLANTABLE ELECTRONIC DEVICES<br>116. Implantable cardioverter defibrillators: technical aspects<br>117. Implantable cardioverter defibrillators: clinical aspects<br>118. Subcutaneous implantable defibrillator<br>119. Implantable pacemakers<br>120. Cardiac resynchronization therapy<br>121. Newer applications of pacemakers<br>122. Remote monitoring<br><br>Section 17 CATHETER ABLATION<br>123. Catheter ablation: Technical aspects<br>124. Catheter ablation: Clinical aspects<br>125. Ablation for atrial fibrillation<br>126. Ablation of supraventricular tachycardias<br>127. Catheter ablation for ventricular tachycardias with/without structural heart disease<br>128. Epicardial and other approaches<br>129. Ventricular fibrillation<br>130. Ablation in pediatrics<br>131. Congenital heart disease<br>132. Anesthesiology for EP procedures<br><br>Section 18: SURGERY FOR ARRHYTHMIAS<br>133. Surgery for atrial fibrillation and other supraventricular tachycardias<br>134. Surgery for ventricular tachycardia<br><br>Section 19 NEW APPROACHES<br>135. Cervical vagal stimulation for heart failure<br>136. Baroreflex stimulation<br>137. Spinal cord stimulation for heart failure and arrhythmias<br>138. Renal artery denervation<br>139. Left atrial appendage occlusion/ligation