Peter C. Hindmarsh,
Kathy Geertsma
Elsevier Science
e druk, 2024
9780128245484
Replacement Therapies in Adrenal Insufficiency
Specificaties
Paperback, blz.
|
Engels
Elsevier Science |
e druk, 2024
ISBN13: 9780128245484
Rubricering
Levertijd ongeveer 8 werkdagen
Samenvatting
Replacement Therapies in Adrenal Insufficiency provides a thorough understanding of the conditions which result in adrenal insufficiency. Never before has one source of information combined all updates on current causes and mechanisms of adrenal sufficiency to allow for quick reference and subsequent treatment decisions. Scientific data on this broad condition includes specific disease coverage of Addison’s disease, hypopituitarism, congenital adrenal hypoplasia and adrenalectomy. Practical points in diagnosis, dosing, drug interactions, replacement therapies and emergency situations are also provided as guidance for overall management.
Specificaties
Inhoudsopgave
1. Why do we need to get hydrocortisone replacement right?<br>2. Mortality and morbidity data<br>3. Side effects and survey results of quality of life<br>4. Oral Glucocorticoid replacement<br>5. What is dosing regimen<br>6. How to calculate daily dose<br>7. How to distribute the dose<br>8. Drug interactions including drugs that alter liver metabolism<br>9. Specific problems with hormone replacement – oral or transdermal estrogens<br>10. Interplay of cortisol and vasopressin – diagnosis of diabetes insipidus and DDAVP replacement<br>11. Pituitary replacement that may modify hydrocortisone dosing – thyroxine and growth hormone<br>12. Monitoring replacement<br>13. What’s missing what are we replacing what should we check<br>14. Ways of checking 17OHP, ACTH cortisol<br>15. Single sample versus multiple samples<br>16. Around dose sampling<br>17. Effects of OCP<br>18. Adjusting doses for events<br>19. Illness and the boxes<br>20. Stressful events<br>21. Surgery<br>22. Dental and the boxes<br>23. Travel and time zones<br>24. Adjustments and effects on other hormones e.g. DDAVP<br>25. Glucocorticoid replacement using pump therapy<br>26. Pump therapy to mimic circadian rhythm<br>27. Principles of the pump<br>28. Setting the system up, clearance studies<br>29. Monitoring replacement<br>30. Quality of life<br>31. Managing an Adrenal Crisis<br>32. Presentation as new diagnosis or following diagnosis<br>33. What it is and what it is not<br>34. Biochemical changes<br>35. How to manage a crisis - at home, in A&E after admission<br>36. Hydrocortisone requirements in a crisis<br>37. Glucose requirements during a crisis<br>38. Sodium and fluid balance - the importance of subacute or chronic hyponatraemia<br>39. Hyperkalaemia<br>40. Weaning Glucocorticoids<br>41. Factors influencing adrenal suppression dose, type of steroid, how long given, potency and whether given during day or night<br>42. The role of alternate day treatments<br>43. Principles in weaning<br>44. How to wean depending on duration of exposure, disease activity steroid used<br>45. What tests to use to determine axis recovery