Twentieth Century Mouse Genetics

1. The origins of mouse genetics and the discovery of the T-locus<br>2. The evolutionary modern synthesis, t-haplotypes in the wild, and reproductive isolation<br>3. Linkage studies, cytogenetics, and the discovery that t-haplotypes consist of a series of inversions—an over-the-Century Project<br>4. Developmental genetics and recessive t-lethals<br>5. More population genetics with particular attention to the effects of t-allele mediated transmission ratio distortion<br>6. Mutation studies including those targeting the T/t-complex—a century long project<br>7. Immunogenetics and the failed search for t-antigens–from mid-century and continuing to it’s end<br>8. Gametogenesis and the genetics of gametes, including t-haplotype segregation distortion<br>9. The cloning era and the cloning of Brachury and other T/t complex genes<br>10. X-inactivation, epigenetics, and imprinting, including of the T/t complex<br>11. Sex determination, sex differentiation, and the Y chromosome—a mostly last quarter of the century effort<br>12. Pharmacogenetics—a mostly last half of the century effort<br>Book Bibliography