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Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2022
ISBN13: 9780128210444
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Elsevier Science e druk, 2022 9780128210444
€ 263,80
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Samenvatting

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters.

Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately. 

Specificaties

ISBN13:9780128210444
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>1. Toxicology Pathology: An Introduction</p> <p>Part 1 Principles of Toxicologic Pathology<br>2. Biochemical and Molecular Basis of Toxicity<br>3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective<br>4. Biotherapeutic ADME and PK/PD Principles<br>5. Principles of Pharmacodynamics and Toxicodynamics<br>6. Morphologic Manifestations of Toxic Cell Injury<br>7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity<br>8. Carcinogenesis: Mechanisms and Evaluation</p> <p>Part 2 Methods in Toxicologic Pathology<br>9. Basic Approaches to Anatomic Toxicologic Pathology<br>10. Clinical Pathology in Nonclinical Toxicity Testing<br>11. Special Techniques in Toxicologic Pathology<br>12. Digital Pathology and Tissue Image Analysis<br>13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models<br>14. Biomarkers: Discovery, Qualification and Application<br>15. Toxicogenomics: A Primer for Toxicologic Pathologists<br>16. Experimental Design and Statistical Analysis for Toxicologic Pathologists</p> <p>Part 3 Animal and Alternative Models in Toxicologic Research<br>17. Animal Models in Toxicologic Research: Rodents<br>18. Animal Models in Toxicologic Research: Rabbit<br>19. Animal Models in Toxicologic Research: Dog<br>20. Animal Models in Toxicologic Research: Pig<br>21. Animal Models in Toxicologic Research: Nonhuman Primate<br>22. Animal Models in Toxicologic Research: Non-mammalian<br>23. Genetically Engineered Animal Models in Toxicologic Research<br>24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Non-Traditional In Vivo Approaches</p> <p>Part 4 Practice of Toxicologic Pathology<br>25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology<br>26. Pathology Peer Review<br>27. Pathology and GLPs, Quality Control and Quality Assurance<br>28. Practices to Optimize Generation, Interpretation, And Reporting of Pathology Data from Toxicity Studies <br>29. Issues in Laboratory Animal Science that Impact Toxicologic Pathology</p>
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        Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology