Preface & Intro & Acknowledgements<br>Richa Salwan<br>Physiological aspects<br>1. Overview of extremophiles<br>Richa Salwan and Vivek Sharma<br>2. Physiology of Extremophiles<br>Richa Salwan and Vivek Sharma<br>3. Mechanism of resistance focusing on copper, mercury and arsenic in extremophilic organisms, how acidophiles and thermophiles cope with these metals<br>Javiera Alejrandra Norambuena<br>4. Halotolerant microbes and their applications in sustainable agriculture<br>Suprasanna Penna, Jayant Kulkarni, Sandeep Sharma and Ashish Kumar Srivastava<br>5. Halophilic microorganisms: interesting group of extremophiles with important applications in biotechnology and environment<br>Lobna Daoud and Mamdouh Ben Ali<br>6. Overview of extremophiles and their food and medical applications<br>Jane Ann Irwin<br>7. Applications of extremophiles in Astrobiology<br>Rebecca S. Thombre, Parag A. Vaishampayan and Felipe Gomez<br>8. High-pressureAdaptation ofExtremophiles and Biotechnological Applications<br>Philippe Oger, Judith Peters and Marta Salvador-Castell<br>9. Fructanogenic Halophiles: A new Perspective on Extremophiles<br>Ebru Toksoy Oner, Gülbahar Abaramak and Onur Kirtel<br>10. Applications of sulfur-oxidizing bacteria<br>Kavita Rana, Neerja Rana and Birbal Singh<br>11. Physiological and genomic perspective of extremophiles in high salt concentrations<br>Preeti Mehta, Ashish Verma and Sachin Kumar Biotechnological aspects<br>12. Genome editing in extremophiles using CRISPR/Cas9 technology<br>Vivek Sharma and Richa Salwan<br>13. Lipases/esterases from extremophiles: main features and potential biotechnological applications<br>Luigi Mandrich and Valentina De Luca<br>14. Thermostable ThermoanaerobacterAlcohol Dehydrogenases And Their Use In Organic Synthesis<br>Sean Michael Scully and Johann Orlygsson Sr.<br>15. Biotechnological platforms of the moderate thermophiles, Geobacillus species: notable properties and genetic tools<br>Hirokazu Suzuki and Keisuke Wada<br>16. Thermophiles and Thermophilic Hydrolases<br>Shilpi Ghosh and Khusboo Lepcha<br>17. Effects of single nucleotide mutations in the genomes of multi-drug resistant 19biofilm producing Pseudomonas aeruginosa<br>Babu Ramanathan, Sanjay Gunabalan and Chew Jactty<br>18. Understanding the structural basis of adaptation in enzymes from psychrophiles<br>Mahejibin Khan<br>19. Molecular and functional characterization of major compatible solute in Deep Sea halophilic actinobacteria of active volcanic Barren Island, Andaman and Nicobar Islands, India<br>Balakrishnan Meena, Lawrance Anburajan and Ramalingam Kirubagaran<br>20. Antarctic microorganisms as a source of biotechnological products<br>Fernanda Abreu and Tarcisio Correa<br>21. The Secretomes of Extremophiles<br>Mazen Saleh and Eyad Kinkar<br>22. Carbonic anhydrase from extremophiles and their potential use in biotechnological applications<br>Clemente Capasso and Claudiu Supuran<br>23. Understanding the Protein Sequence and Structural Adaptation in Extremophilic Organisms through Machine Learning Techniques<br>Abhigyan Nath<br>24. Exploration of extremophiles genomes through metagenomics for hidden Biotechnological and future potential<br>Pijush Basak, Arpita Biswas and Maitree Bhattacharyya<br>25. The Ecophysiology, Genetics, Adaptive Significance, and Biotechnology of Nickel Hyperaccumulation in Plants<br>Anthony Logan Ferrero, Peter R. Walsh and Nishanta Rajakaruna