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Carbonic Anhydrases

Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target

Specificaties
Paperback, blz. | Engels
Elsevier Science | e druk, 2019
ISBN13: 9780128164761
Rubricering
Elsevier Science e druk, 2019 9780128164761
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health.

Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs.

Specificaties

ISBN13:9780128164761
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

1. Carbonic Anhydrases: An Overview<br>2. α-Carbonic Anhydrases<br>3. β-Carbonic Anhydrases<br>4. γ-Carbonic Anhydrases<br>5. δ-Carbonic Anhydrases<br>6. ζ-Carbonic Anhydrases<br>7. η and θ-Carbonic Anhydrases<br>8. Human Carbonic Anhydrases: Tissue Distribution, Physiological Role and Druggability<br>9. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Zinc Binders<br>10. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Anchor to The Zinc-Bound Nucleophile<br>11. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds Occluding the Entrance of The Active Site<br>12. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Bind “Out of The Binding Site” And Compounds with An Unknown Mechanism of Action<br>13. Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs for The Treatment of Glaucoma<br>14. Carbonic Anhydrase Inhibitors as Diuretics<br>15. Carbonic Anhydrase Inhibitors for The Treatment of Epilepsy and Obesity<br>16. Carbonic Anhydrase Inhibitors for The Treatment of Tumors: Therapeutic, Immunologic, And Diagnostic Tools Targeting Isoforms IX And XII<br>17. Carbonic Anhydrase Inhibitors for The Treatment of Neuropathic Pain and Arthritis<br>18. Carbonic Anhydrases from Pathogens: Bacterial Cas And Their Inhibitors as Potential Anti-Infectives <br>19. Carbonic Anhydrases from Pathogens: Fungal Cas And Their Inhibitors as Potential Antifungal Agents<br>20. Carbonic Anhydrases from Pathogens: Protozoan Cas And Related Inhibitors as Potential Anti-Protozoal Agents<br>21. Carbonic Anhydrase Activators and Their Potential in The Pharmaceutical Field<br>22. Biotechnological Applications of Carbonic Anhydrases from Extremophiles<br>23. CO2 Capture by Engineered Mammalian Carbonic Anhydrases

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        Carbonic Anhydrases