Genetics and Genomics of Eye Disease

<p>Section I Introduction to gene mapping<br>1. Timeline of key discoveries in eye genetics<br>2. Segregation, Linkage, GWAS, and sequencing</p> <p>Section II Mendelian Disorders and high penetrant mutations<br>3. Inherited retinal degenerations<br>4. Early-onset glaucoma<br>5. Strabismus</p> <p>Section III Complex disorders and low effect-size risk factors<br>6. Age-related macular degeneration<br>7. Adult-onset glaucoma<br>8. Diabetic retinopathy<br>9. Kerotoconus</p> <p>Section IV Genomics in the eye <br>10. Whole-exome sequencing and whole-genome sequencing<br>11. RNA-Seq and transcriptome analysis<br>12. Epigenetics and miRNA regulation</p> <p>Section V Genetic testing and genetic risk prediction  <br>13. Genetic testing of various eye disorders<br>14. Genetic risk scores and complex eye disorders</p> <p>Section VI Gene-based therapy<br>15. Leber congenital amaurosis<br>16. CRISPR/CAS9 technology</p> <p>Section VII Big data and precision medicine<br>17. Machine learning and artificial intelligence<br>18. Vision research in multi-ethnic populations<br>19. Bringing research into the clinic and application to precision medicine</p>