Russell R. Lonser,
Malisa Sarntinoranont,
Kristof Bankiewicz
Elsevier Science
e druk, 2019
9780128139974
Nervous System Drug Delivery
Principles and Practice
Specificaties
Gebonden, blz.
|
Engels
Elsevier Science |
e druk, 2019
ISBN13: 9780128139974
Rubricering
Verwachte levertijd ongeveer 8 werkdagen
Samenvatting
Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.
Specificaties
Inhoudsopgave
<p>Section I. Physiology of Nervous System Drug Delivery<br>1. Fundamentals of Brain–Barrier Anatomy and Global Functions<br>2. Blood-Brain Barrier in Disease States <br>3. Pharmacokinetics of Systemic Drug Delivery<br>4. Pharmacokinetics of Drug Delivery Past the Blood-Brain Barrier<br>5. Anatomy and Physiology of Cerebrospinal fluid Dynamics <br>6. Pharmacokinetics of Polymeric Drug Delivery <br>7. Pharmacokinetic Models of Convection-Enhanced Drug Delivery<br>8. Mechanisms and Clinical Applications of Stem Cell Therapy</p> <p>Section II. Nervous System Drug Delivery Techniques<br>9. Intravenous and Intravascular Drug Delivery<br>10. Blood-Brain Barrier Disruption <br>11. Ultrasonic Methods <br>12. Nanoparticles for Brain Tumor Delivery<br>13. Solute Transport in the Cerebrospinal Fluid: Physiology and Practical Implications<br>14. Drug-impregnated Polymer Delivery <br>15. Immunomodulatory Methods <br>16. Convection-Enhanced Drug Delivery in the Central Nervous System<br>17. Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices <br>18. CRISPR–Cas Gene Editing for Neurological Disease</p> <p>Section III. Clinical Application of Nervous System Drug Delivery<br>19. Drug and Disease-Specific Paradigms for Drug Delivery to the Central Nervous System<br>20. Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Brain Tumors<br>21. Clinical Methods of Nervous System Drug Delivery for Tumors<br>22. Delivery Methods for Treatment of Genetic Disorders<br>23. Direct Convective of Nervous System Drug Delivery for Patients with Neurodegenerative Disorders<br>24. Central Nervous System Drug Delivery after Ischemic or Hemorrhagic Stroke<br>25. Intrathecal Drug Delivery for Cancer Pain</p>