<p>Perspective<br>1. A concise history of the discovery of mammalian nitric oxide (nitrogen monoxide) biogenesis </p> <p>Chemical Biology<br>2. An integrated view of the chemical biology of NO, CO, H2S and O2<br>3. Detection of nitric oxide and related species in biological systems: A state-of-the-art review<br>4. S-nitrosothiols and nitric oxide biology and therapeutics<br>5. Cooperative interactions between NO and H2S: Chemistry, biology, physiology, pathophysiology<br>6. Heme protein metabolism of NO and nitrite</p> <p>Enzymology<br>7. Cross-regulation between iNOS/NO and Wnt/β-catenin signaling pathways<br>8. Regulation and physiological functions of NO-sensitive guanylyl cyclase<br>9. Upcoupling eNOS in cardiovascular disease</p> <p>Biology/Pharmacology<br>10. Synthesis, actions and perspectives of nitric oxide in photosynthetic organisms<br>11. Mitochondria and nitric oxide<br>12. Nitric oxide formation from inorganic nitrate <br>13. Biochemistry of molybdopterin nitrate/nitrite reductases<br>14. NOS, NO and the red cell<br>15. Update on nitrite reduction in ischaemic disease: Mechanisms and clinical translation<br>16. Electrophilic Nitro-Fatty Acids: Nitric Oxide and Nitrite-Derived Signaling Mediators and New Drug Candidates<br>17. Regulation of redox signaling by a nitrated nucleotide and reactive cysteine persulfides<br>18. Diffusional control of nitric oxide in the vessel wall<br>19. Asymmetric-Dimethylarginine<br>20. The role of nitric oxide in epigenetic regulation</p> <p>Inflammation and Pathobiology<br>21. Peroxynitrite formation and detection in living cells<br>22. Nitric oxide in sepsis and hemorrhagic shock: Beneficial or detrimental?<br>23. NO signaling defects in hypertension<br>24. Nitric oxide regulation of cardiovascular physiology and pathophysiology<br>25. Inhaled nitric oxide: Current clinical use and future potential uses and development<br>26. The defective arginine-nitric oxide pathway in sickle cell disease<br>27. Aberrant nitric oxide signaling contributes to protein misfolding in neurodegenerative diseases via S-nitrosylation and tyrosine nitration<br>28. NO in cancer: Carcinogenesis, metastases and therapy</p>
