Developing Therapeutics for Alzheimer's Disease

Progress and Challenges

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2016
ISBN13: 9780128021736
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Elsevier Science e druk, 2016 9780128021736
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Samenvatting

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area.

Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics.

Specificaties

ISBN13:9780128021736
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

1. The Complex Pathways to Mechanism-Based Therapeutics in Alzheimer’s Disease<br>2. The Genetic Basis of Alzheimer's Disease<br>3. B-Secretase Inhibition<br>4. Y-Secretase Inhibitors: from Chemical Probes to Drug Development<br>5. Therapeutic Targeting of AB42<br>6. Modulators of Amyloid B-Protein (AB) Self-Assembly<br>7. Anti-Amyloid-B Immunotherapy for Alzheimer’s Disease<br>8. Targeting AB Receptors to Modify Alzheimer’s Disease Progression<br>9. Blood-Brain Barrier Transport of Alzheimer’s Amyloid B-Peptide<br>10. Alzheimer’s Disease Therapeutics Targeting Apolipoprotein E<br>11. Microtubule Stabilization<br>12. Tau Phosphorylation as a Therapeutic Target in Alzheimer's Disease<br>13. Stimulation of Tau Degradation <br>14. Passive Immunotherapy for Tau Pathology<br>15. Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer’s Disease <br>16. Neuroprotective Strategies for Alzheimer’s Disease Prevention and Therapy<br>17. Symptomatic Cognitive Enhancing Agents<br>18. Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria<br>19. Preclinical and Clinical Issues in Alzheimer Drug Development <br>20. Molecular Imaging in Alzheimer Clinical Trials<br>21. Fluid Biomarkers and Diagnostics <br>22. Non-Pharmacologic Activity Interventions to Prevent Alzheimer’s Disease<br>23. Prospects and Challenges for Alzheimer Therapeutics

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        Developing Therapeutics for Alzheimer's Disease