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Organic Chemistry Concepts and Applications for Medicinal Chemistry

Specificaties
Paperback, blz. | Engels
Elsevier Science | e druk, 2014
ISBN13: 9780128007396
Rubricering
Elsevier Science e druk, 2014 9780128007396
€ 64,54
Levertijd ongeveer 8 werkdagen

Samenvatting

Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams.

Specificaties

ISBN13:9780128007396
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

1. Bonding in Organic Compounds a. Atomic Orbitals b. Hybrid Orbitals c. Resonance d. Aromaticity2. The Three-Dimensional Structure of Organic Compounds a. Isomers b. Stereoisomerism at Saturated Centers c. Prochirality d. Conformations3. Functional Groups a. Common Functional Groups b. The Electronic Effects of Functional Groups4. Acids and Bases a. Bronsted-Lowry Acids and Bases b. Ionization c. Estimating Acid/Base Strength d. Lewis Acids and Bases5. Partition Coefficients a. What is a Partition Coefficient? b. Effect of Structure on Partition Coefficients6. The Nomenclature of Cyclic and Polycyclic Compounds a. Common Heterocycles b. Fused-Ring Systems c. Substituents and Saturation d. Bridged-Rings e. Spiro-Rings f. Special Classes of Compounds i. Steroids ii. Prostaglandins iii. Morphinans7. Drug Metabolism a. Phase I – Oxidative Processes b. Phase I – Reductions c. Phase I – Hydrolysis d. Phase II – Conjugation e. Miscellaneous Phase II Processes
€ 64,54
Levertijd ongeveer 8 werkdagen

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        Organic Chemistry Concepts and Applications for Medicinal Chemistry