Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2014
ISBN13: 9780128001868
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Elsevier Science e druk, 2014 9780128001868
€ 114,94
Levertijd ongeveer 8 werkdagen

Samenvatting

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

Specificaties

ISBN13:9780128001868
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>1. Protein misfolding, neurodegeneration and Tau: The main players, or the usual suspects?2. Targeting the protein quality control (PQC) machinery: The neuronal Salvation Army3. Proteasomal degradation of soluble, misfolded proteins: Throwing out the bath water, but where’s the baby?4. Unselective disposal of cellular aggregates: Engulf, devour and digest to recycle5. Selective disposal of insoluble protein aggregates: Pick, transport and remove to cure6. Assembly and disassembly of protein aggregates: Unraveling the maze</p>
€ 114,94
Levertijd ongeveer 8 werkdagen

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        Molecular Targets in Protein Misfolding and Neurodegenerative Disease