TRP Channels as Therapeutic Targets

1. Introduction<br>2. Hereditary TRP Channelopathies<br>3. Changes in TRP Channel Expression in Acquired Diseases<br>4. TRP Gene Polymorphism and Disease Risk<br>5. Topical Capsaicin for Pain Relief<br>6. TRPV1 agonist cytotoxicity for chronic pain relief<br>7. Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders<br>8. Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents <br>9. TRPA1 Antagonists for Pain Relief<br>10. TRPA Antagonistsas Therapeutic Strategies to Reduce the Symptoms and Pathophysiology of Respiratory Disorders<br>11. TRPV3 Receptors as Drug Targets: A Decade of Learning<br>12. Small Molecule Agonists and Antagonists of TRPV4<br>13. Potential Therapeutic Applications for TRPV4 Antagonists in Lung Disease<br>14. TRPM8 as a Target for Analgesia<br>15. TRP Channels: Connectivity to Cerebral Vascular Disease<br>16. TRP Channels' Key Role in the Transduction of Itch<br>17. Role of TRP Channels in Skin Diseases<br>18. TRP Channels in Obesity/Metabolic Syndrome<br>19. TRP Channels in Diabetes<br>20. TRP Channels and Ca²+ Entry in Cardiac Disease<br>21. The Contribution of TRP Channels to Pathophysiological Regulation of the Gastrointestinal Tract<br>22. Cancer: Oncogenic and Anti-Oncogenic TRP Channels as Biomarkers and Therapeutic Targets<br>23. TRP Channels in the Brain<br>24. A: Mucolipidosis and TRPML Channels<br>24 B: TRPML1-dependent Processes as the Therapeutic Targets<br>25. TRPs in respiratory disorders: opportunities beyond TRPA1<br>26. Concluding Remarks