Molecular Biology of B Cells

<p>1. Ig loci: structure and expression regulation</p> <p>2. The mechanisms of V(D)J recombination</p> <p>3. Transcriptional regulation of B lymphocyte differentiation</p> <p>4. B cell transcriptome </p> <p>5. The role of microRNA in B cell development and function </p> <p>6. Proliferation and differentiation program of developing B cells </p> <p>7. Development and function of B cell subsets</p> <p>8. Evolution of primordial B cell antigen receptor</p> <p>9. The evolutionary origin of V(D)J diversification </p> <p>10. Receptor organization on B cells and its signaling</p> <p>11. Fc and complement responses</p> <p>12. The dynamic structure of germinal center: generation of high affinity Ab</p> <p>13. Cell Migration</p> <p>14. B cell as regulator</p> <p>15. B cell memory and plasma cell development</p> <p>16. Roles of lymphotoxin and Baff on B cells</p> <p>17. The mucosal immune system: host-bacteria interaction and regulation of IgA synthesis</p> <p>18. Gut microbiota and their regulation</p> <p>19. Regulation and function of activation-induced cytidine deaminase</p> <p>20. Molecular mechanism of CSR</p> <p>21. Molecular mechanism of SHM</p> <p>22. Aberrant AID expression by pathogen infection</p> <p>23. Chromosomal translocation and mutations in B cell leukemia and lymphomas</p> <p>24. B cells producing pathogenic autoantibodies</p> <p>25. HIV neutralizing Ab</p> <p>26. Immune deficiency caused by B cell defects</p> <p>27. IMGT® for immunoglobulin repertoire analysis and antibody humanization</p> <p>28. Humanized monoclonal Ab production</p> <p>29. Ab therapy against lymphoma</p> <p>30. Anti-interleukin-6 receptor antibody therapy against autoimmune inflammatory diseases</p> <p>31. Ab therapy against chronic inflammatory immune-mediated diseases</p>