The Role of Sphingolipids in Cancer Development and Therapy

<ol> <li>Therapeutic potential of targeting SK1 in human cancers</li> <li>Natural products as platforms for the design of sphingolipid derived anticancer agents</li> <li>Hypoxia, therapeutic resistance and sphingosine 1-phosphate</li> <li>Use of acid sphingomyelinase for cancer therapy</li> <li>Diverse functions of ceramide on cancer cell death and proliferation</li> <li>Sphingosine kinase and cancer</li> <li>Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance</li> <li>Interdiction of sphingolipid metabolism to improve standard of care cancer therapies<br></li></ol>