Genetics of Bone Biology and Skeletal Disease

Part I: General Background to Bone Biology<br>1. Biology of Bone and Cartilage<br>Brendan Boyce, Michael Zuscik, Lianping Xing<br>2. Overview of Bone Structure and Strength<br>Mary L. Bouxsein<br>3. Overview of Joint and Cartilage Biology<br>Frank Luyten and Rik JU Lories<br>4. Integrating Endocrine and Paracrine Influences on Bone: Lessons from Parathyroid Hormone and Parathyroid Hormone-related Protein<br>T. John Martin and Natalie A. Sims<br>5. Energy Homeostasis and Neuronal Regulation of Bone Remodeling<br>Gerard Karsenty, Mathieu Ferron and Franck Oury<br>6. Neuropeptide Y and Bone Regulation<br>Paul A. Baldock<br><br>Part II: General Background to Genetics<br>7. Genome-wide Association Studies<br>Matthew Brown and Emma L. Duncan<br>8. Genomic Profiling in Bone<br>Gabriela G. Loots and Bryan D. Hudson<br>9. Copy Number Variation<br>Hong-Wen Deng, Tie-Lin Yang, Yan Guo and Christopher J. Papasian<br>10. Prospects of Gene Therapy<br>Brendan Lee, Merry ZC Ruan and Kilian Guse<br>11. Pharmacogentics and Pharmacogenomics of Osteoporosis: Personalized Medicine Outlook<br>Tuan V. Nguyen and John A. Eisman<br>12. Genetic Testing & Counselling<br>Ingrid A. Holm, Christina M. Jacobsen, Yiping Shen and Stephanie J. Brewster<br>13. Mouse models: Approaches to Generating in vivo Models for Hereditary Disorders of Mineral and Skeletal Homeostasis<br>Sian E. Piret and Rajesh V. Thakker<br>14. Fetal Control of Calcium and Phosphate Homeostasis – Lessons from Mouse Models<br>Christopher S. Kovacs<br>15. Control of Skeletal Homeostasis during Pregnancy and Lactation – Lessons from Physiological Models<br>Christopher S. Kovacs<br><br>Part III: Disorders of Bone and Joint<br>16. Osteogenesis Imperfecta<br>Joan Marini and M. Helen Rajpar<br>17. Osteoporosis Genes Identified by Genome-wide Association Studies<br>Andre Uitterlinden and Fernando Rivadenerira<br>18. Osteoarthritis – Genetic Studies of Monogenic and Complex Forms<br>Ana M. Valdes<br>19. Paget’s Disease<br>Stuart H. Ralston and Omar M.E. Albagha<br>20. Heritable Disorders of RANKL, OPG, RANK and NF-KB Signalling<br>Michael Whyte<br>21. Skeletal Dysplasias<br>William G. Cole<br>22. Hypophosphatasia<br>Michael P. Whyte<br>23. Sclerosing Bone Disorders<br>Bram Perdu and Wim Van Hul<br>24. Fibrodysplasia (Myositis) Ossificans Progressiva<br>Andria L. Culbert, Salin A. Chakkalakal, Michael R. Convente, Vitali Y. Lounev, Frederick S. Kaplan and Eileen M. Shore<br><br>Part IV: Parathyroid and Related Disorders<br>25. Hyperparathyroidism<br>Andrew Arnold and Jessica Costa-Guda<br>26. Hypoparathyroidism<br>Rajesh V. Thakker<br>27. Gsa, Pseudohypoparathyroidism, Fibrous Dysplasia, and McCune-Albright Syndrome<br>Lee S. Weinstein, Allen M. Spiegel and Michael Collins<br>28. Genetic disorders affecting PTH/PTHrP receptor function<br>Harald Jueppner and Caroline Silve<br>29. Genetically Determined Disorders of the Calcium-Sensing Receptor<br>Edward M. Brown and Ogo I. Egbuna<br>30. Multiple Endocrine Neoplasia Type 1 (MEN1)<br>Rajesh V. Thakker<br>31. Multiple Endocrine Neoplasia Type 2 (MEN2)<br>Bruce Robinson, Rory Clifton-Bligh and Matti Gild<br><br>Part V: Vitamin D and Renal Disorders<br>32. Heritable Renal Phosphate Wasting Disorders<br>Marc K. Drezner<br>33. Genetic Disorders of Vitamin D Synthesis and Action<br>David Feldman, Peter Malloy and Walter L. Miller<br>34. Renal Fanconi Syndrome, Dent's Disease and Bartter's Syndrome<br>Olivier Devuyst and Takashi Igarashi<br>35. Inherited Magnesium Disorders<br>Scott J. Schurman, Dhruval Patel, Anil Singh and Steven J. Scheinman<br>36. Genetic Hypercalciuria: A Major Risk Factor in Kidney Stones<br>David Bushinsky and Orson W. Moe