Modifications of Nuclear DNA and its Regulatory Proteins

<p>1. Introduction – Epiphanies in Epigenetics<br>Xiaodong Cheng<SUP> </SUP>and Robert M. Blumenthal</p> <p>Section I. EVOLUTION OF DNA METHYLATION<br>2. The natural history of eukaryotic DNA methylation systems<br>Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind<br>3. Evolution of histone methyltransferases and demethylases<br>L. Aravind<br>4. DNA methylation in Drosophila – A critical evaluation<br>Veiko Krauss and Gunter Reuter<br>5. DNA Methylation in Zebrafish<br>Mary G Goll<SUP> </SUP>and Marnie E Halpern</p> <p>Seciton II. MAMMALIAN DNA METHYLTRANSFERASES – STRUCTURE AND FUNCTION<br>6. Dnmt1 - structure and function<br>Željko M. Svedružić<br>7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases<br>Frédéric Chédin</p> <p>Seciton III. DNA METHYLATION AND DEMETHYLATION<br>8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors<br>Jafar Sharif & Haruhiko Koseki<br>9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells<br>Shannon R. Morey Kinney and Sriharsa Pradhan<br>10. Mechanistic and functional links between histone methylation and DNA methylation<br>Taiping Chen</p> <p>Section IV. DNA METHYLATION IN MEDICINE<br>11. RNA mediated silencing mechanisms in mammalian cells<br>Anton Wutz<br>12. Biological functions of methyl-CpG binding proteins<br>Pierre-Antoine Defossez and Irina Stancheva</p> <p>Section V. DNA METHYLATION IN MEDICINE<br>13. Diseases associated with imprinting<br>J.F. Wilkins and F. Úbeda<br>14. DNA methylation changes in cancer<br>Minoru Toyota and Eiichiro Yamamoto<br>15. Epigenetic biomarkers<br>J. Tost<br>16. Distribution of methylation at the single-nucleotide level<br>E.  </p>