Advances in Enzyme Regulation

Acknowledgements. List of Participants. Session I. Inositide Signaling: J.G. Cory. Re-examination of the significance of nuclear localization of PLC&bgr;1 in the likelihood of its involvement in neoplastic cell growth (L. Cocco, L. Manzoli et al.). The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases (K. Backers, D. Blero, et al.). Session II. Drug targeting and resistance: L. Cocco. Inhibitors<br>of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: Convergence at Caspase-3 activation (A.H. Cory, C.C. Edwards et al.). Targeting signal transduction (G. Weber, F. Shen et al.). Session III. Tumor Metabolism: J.J. Starling. Utilization of the promoter region of the midkine gene as a tool to drive therapeutic genes in a tumor specific manner (S. Sakiyama, L. Yu et al.). Opportunities for studying cancer by metabolomics: Preliminary observations on tumors deficient in hypoxia-inducible factor 1 (J.R. Griffiths, M. Stubbs). Session IV. Control of Phospholipase: O. Greengard. Structural and mechanistic aspects of phosphoinositide C&ggr; regulation (M. Katan, R. Rodriguez et al.). Phospholipase C&dgr;: From<br>genome structure to physiological function (K. Fukami, T. Inoue et al.). Activation of PI(4)P 5-kinase by small G proteins (Y. Kanaho, H. Miyazaki, M. Yamazaki). Session V. Oxidative Stress: N. Katunuma. Importance of phase 2 gene regulation in protection against electrophile<br>and reactive oxygen toxicity and carcinogenesis (P. Talalay, A.T. Dinkova-Kostova, W.D. Holtzclaw). Ferritin regulation by oxidants and chemopreventive xenobiotics (J. Wilkinson, E.C. Pietsch IV et al.). Session VI. Regulation of gene expression: J.R. Griffiths. The regulation of adipocyte metabolism and gene expression by interleukin-11 (R. Tenney, J.R. Turnbull et al.). A comprehensive model for<br>the allosteric regulation of class Ia ribonucleotide reductase (B.S. Cooperman, O.B. Kashlan). Raf kinases in lung tumor development (Rapp U.R., J. Fensterle et al.). Session VII. Regulation of Cell Proliferation: M. Stubbs. Interaction of cofilin with serine<br>phosphatases PP1 and PP2A in normal and neoplastic human T<br>lymphocytes (Y. Samstag, G. Nebl). Regulation of cell survival by<br>atypical protein kinase C isozymes (H.H. Grunicke, M. Spitaler, et al.). Session VIII. Translocation and Activation: H.H. Grunicke. Regulation of cytosolic<br>phospholipase A<INF>2</INF> translocation (J.H. Evans, D.J. Fergus, C.C. Leslie). On the mechanism coupling phospholipase C&ggr;1 to<br>the B- and T-cell antigen receptors (E. Bonvini, K.E. DeBel, et al.). Session IX. Evolutionary Analysis: R.A. Harris. Interpretive proteomics - Finding biological meaning in genome and proteome databases (S.A. Benner). Clostridum perfringens iota-toxin, ADP-ribosyltransferase: Structure and mechanism of action (J. Sakurai, M. Nagahama et al.). Session X. Signaling Pathway Interference: S.A. Benner. Dissection<br>of signal-regulated transcriptional modules by signaling pathway<br>interference in oncogene-transformed cells (R. Sch&auml;fer, O.I. Tchernitsa et al.). New cysteine protease<br>inhibitors in physiological secretory fluids and their medical significance (N. Katunuma, A. Ohashi et al.). Session XI. Special Symposium Lecture: P. Talalay. At the nucleus of the problem: Nuclear proteins and disease (N.M. Maraldi, G. Lattanzi et al.). Author Index. Subject Index. Contents of Recent Volumes.