Modern Magnetic Resonance
Part 1: Applications in Chemistry, Biological and Marine Sciences, Part 2: Applications in Medical and Pharmaceutical Sciences, Part 3: Applications in Materials Science and Food Science
Samenvatting
A comprehensive collection of the applications of Nuclear Magnetic Resonance (NMR), Magnetic Resonance Imaging (MRI) and Electron-Spin Resonance (ESR).
Covers the wide ranging disciplines in which these techniques are used:
* Chemistry;
* Biological Sciences;
* Pharmaceutical Sciences;
* Medical uses;
* Marine Science;
* Materials Science;
* Food Science.
Illustrates many techniques through the applications described, e.g.:
* High resolution solid and liquid state NMR;
* Low resolution NMR, especially important in food science;
* Solution State NMR, especially important in pharmaceutical sciences;
* Magnetic Resonance Imaging, especially important for medical uses;
* Electron Spin Resonance, especially important for spin-labelling in food, marine and medical studies.
Specificaties
Inhoudsopgave
<P>· Amyloids </P>
<P>o Kinetics of Amyloid Fibril Formation of Human Calcitonin.</P>
<P>o Polymorphism of Alzheimer’s A-beta Amyloid Fibrils.</P>
<P>· Chemical Shifts and Spin-Couplings. </P>
<P>o <SUP>13</SUP>C, <SUP>15</SUP>N, <SUP>1</SUP>H, <SUP>2</SUP>H, and <SUP>17</SUP>O NMR Chemical Shift NMR for Hydrogen Bonds. </P>
<P>o NMR Chemical Shift Map. </P>
<P>o NMR Chemical Shifts Based on Band Theory.</P>
<P>o Modeling NMR Chemical Shifts. </P>
<P>o Ab Initio Calculation of NMR Shielding Constants. </P>
<P>o Crystal Structure Refinement Using Chemical Shifts. </P>
<P>o The Theory of Nuclear Spin–Spin Couplings.</P>
<P>· Fibrous Proteins.</P>
<P>o Investigation of Collagen Dynamics by Solid-State NMR Spectroscopy.</P>
<P>o Solid-State NMR Studies of Elastin and Elastin Peptides.</P>
<P>o Structural Analysis of Silk Fibroins using NMR.</P>
<P>· Field Gradient NMR.</P>
<P>o NMR Diffusometry. </P>
<P>o Field Gradient NMR of Liquid Crystals. </P>
<P>o Field Gradient NMR for Polymer Systems with Cavities. </P>
<P>o NMR Measurements Using Field Gradients and Spatial Information. </P>
<P>o Theory and Application of NMR Diffusion Studies. </P>
<P>· Host–Guest Chemistry. </P>
<P>o Solid-State NMR in Host–Guest Chemistry. </P>
<P>· Imaging. </P>
<P>o Mapping of Flow and Acceleration with NMR Microscopy Techniques. </P>
<P>o Industrial Application of In situ NMR Imaging Experiments to Steel-Making Process. </P>
<P>o Biomedical NMR Spectroscopy and Imaging. </P>
<P>o Electron Spin Resonance Imaging in Polymer Research. </P>
<P>o NMR Imaging: Monitoring of Swelling of Environmental Sensitive Hydrogels. </P>
<P>· Inorganic Materials and Catalysis. </P>
<P>o Exploiting <SUP>1</SUP>Hà <SUP>29</SUP>Si Cross-Polarization Features for Structural Characterization of Inorganic Materials. </P>
<P>o Solid State NMR Characterization of Solid Surface of Heterogeneous Catalysts. </P>
<P>· Isotope Labeling. </P>
<P>o Recent Developments in Stable-Isotope-Aided Methods for Protein NMR Spectroscopy. </P>
<P>o Structural Glycobiology by Stable-isotope-assisted NMR Spectroscopy. </P>
<P>· Lipid Bilayer and Bicelle. </P>
<P>o Development and Application of Bicelles for Use in Biological NMR and Other Biophysical Studies. </P>
<P>o Nuclear Magnetic Resonance of Oriented Bilayer Systems. </P>
<P>o Solid-State Deuterium NMR Spectroscopy of Membranes. </P>
<P>o Solid State <SUP>19</SUP>F-NMR Analysis of Oriented Biomembranes. </P>
<P>· Membrane-Associated Peptides. </P>
<P>o Solid-State NMR Studies of the Interactions and Structure of Antimicrobial Peptides in Model Membranes. </P>
<P>o Anisotropic Chemical Shift Perturbation Induced by Ions in Conducting Channels. </P>
<P>o NMR Studies of Ion-Transporting Biological Channels. </P>
<P>· Membrane Proteins. </P>
<P>o Site-Directed NMR Studies on Membrane Proteins. </P>
<P>o Structure of Membrane-Binding Proteins Revealed by Solid-State NMR. </P>
<P>o Solid-State NMR of Membrane-Active Proteins and Peptides. </P>
<P>o Magnetic Resonance Spectroscopic Studies of the Integral Membrane Protein Phospholamban. </P>
<P>o NMR Studies of the Interactions Between Ligands and Membrane-Embedded. Receptors: New Methods for Drug Discovery. </P>
<P>o Photosynthetic Antennae and Reaction Centers. </P>
<P>o Insight into Membrane Protein Structure from High-Resolution NMR. </P>
<P>· New Developments. </P>
<P>o Fast Multidimensional NMR: New Ways to Explore Evolution Space. </P>
<P>o High-Sensitivity NMR Probe Systems. </P>
<P>o CRAMPS. </P>
<P>o Mobile NMR. </P>
<P>o Rheo-NMR. </P>
<P>o Analytical Aspects of Solid-State NMR Spectroscopy. </P>
<P>o <SUP>3</SUP>H NMR and Its Application. </P>
<P>o On-line SEC–NMR. </P>
<P>· NOE and Chemical Exchange. </P>
<P>o The Nuclear Overhauser Effect. </P>
<P>o Solute–Solvent Interactions Examined by the Nuclear Overhauser Effect. </P>
<P>o Chemical Exchange. </P>
<P>· NQR & ESR. </P>
<P>o Separated Detection of H-Transfer Motions in Multi-H-Bonded Systems Studied by Combined <SUP>1</SUP>H NMR and <SUP>35</SUP>Cl NQR Measurements. </P>
<P>o EPR: Principles. </P>
<P>o Zero Field NMR: NMR and NQR in Zero Magnetic Field. </P>
<P>· Organo Metallic Chemistry. </P>
<P>o Organoboron Chemistry. </P>
<P>o Organogermanium Chemistry. </P>
<P>o Organotin Chemistry. </P>
<P>· Paramagnetic Effects. </P>
<P>o <SUP>1</SUP>H and <SUP>13</SUP>C High-Resolution Solid-State NMR of Paramagnetic Compounds Under Very Fast Magic Angle Spinning. </P>
<P>o Paramagnetic Effects of Dioxygen in Solution NMR—Studies of Membrane Immersion Depth, Protein Topology, and Protein Interactions. </P>
<P>· Protein Structure. </P>
<P>o TROSY NMR for Studies of Large Biological Macromolecules in Solution. </P>
<P>o NMR Insight of Structural Stability and Folding of Calcium-Binding Lysozyme. </P>
<P>o NMR Investigation of Calmodulin. </P>
<P>o Analytical Framework for Protein Structure Determination by Solid-State NMR of Aligned Samples. </P>
<P>o Determining Protein 3D Structure by Magic Angle Spinning NMR. </P>
<P>o <SUP>19</SUP>F NMR Study of b-Type Haemoproteins. </P>
<P>· Polymer Structure. </P>
<P>o NMR in Dry or Swollen Temporary or Permanent Networks. </P>
<P>o Crystalline Structure of Ethylene Copolymers and Its Relation to the Comonomer Content. </P>
<P>o Isomorphism in Bacterially Synthesized Biodegradable Copolyesters. </P>
<P>o Two-Dimensional NMR Analysis of Stereoregularity of Polymers. </P>
<P>o Quantitative Analysis of Conformations in Disordered Polymers by Solid-State Multiple-Quantum NMR. </P>
<P>o Polymer Microstructure: The Conformational Connection to NMR. </P>
<P>o Solid-State NMR Characterization of Polymer Interfaces. </P>
<P>o The Structure of Polymer Networks. </P>
<P>o <SUP>1</SUP>H CRAMPS NMR of Polypeptides in the Solid State. </P>
<P>· Polymer Dynamics. </P>
<P>o Dynamics of Amorphous Polymers. </P>
<P>o Molecular Motions of Crystalline Polymers by Solid-State MAS NMR. </P>
<P>o Dynamics in Polypeptides by Solid State 2H NMR. </P>
<P>· Polymer Blends. </P>
<P>o Polymer Blends. </P>
<P>o Configurational Entropy and Polymer Miscibility: New Experimental Insights From Solid-State NMR. </P>
<P>· Quantum Information Processing. </P>
<P>o Quantum Information Processing as Studied by Molecule-Based Pulsed ENDOR Spectroscopy. </P>
<P>· Residual Dipolar Couplings and Nucleic Acids. </P>
<P>o New Applications for Residual Dipolar Couplings: Extending the Range of NMR in Structural Biology. </P>
<P>o Refinement of Nucleic Acid Structures with Residual Dipolar Coupling Restraints in Cartesian Coordinate. </P>
<P>o Conformational Analysis of DNA and RNA. </P>
<P>· Solid-State NMR Technique. </P>
<P>o Analytical and Numerical Tools for Experiment Design in Solid-State NMR Spectroscopy. </P>
<P>o Homonuclear Shift-Correlation Experiment in Solids. </P>
<P>o Two-Dimensional <SUP>17</SUP>O Multiple-Quantum Magic-Angle Spinning NMR of Organic Solids. </P>
<P>o A Family of PISEMA Experiments for Structural Studies of Biological Solids.</P>
<P>· Structural Constraints in Solids. </P>
<P>o Rotational-Echo, Double-Resonance NMR. </P>
<P>o REDOR in Multiple Spin System. </P>
<P>o Torsion Angle Determination by Solid-State NMR. </P>
<P>o Secondary Structure Analysis of Proteins from Angle-Dependent Interactions.</P>
<P>· Telomeric DNA Complexes. </P>
<P>o Comparison of DNA-Binding Activities Between hTRF2 and hTRF1 with hTRF2 Mutants. </P>
<P>o Optimization of MRI Contrast for Pre-Clinical Studies at High Magnetic Field. </P>
<P>o The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease. </P>
<P>o Experimental Models of Brain Disease: MRI Contrast Mechanisms for the Assessment of Pathophysiological Status. </P>
<P>o Experimental Models of Brain Disease: MRI Studies. </P>
<P>o Application of MRS in Cancer in Pre-clinical Models. </P>
<P>o Experimental Cardiovascular MR in Small Animals. </P>
<P>o Application of Pharmacological MRI to Preclinical Drug Discovery and Development. </P>
<P>o Application of MRI to Cell Tracking. </P>
<P>· Marine Science</P>
<P>o Comprehensive Compositional Analysis of Fish Feed by Time Domain NMR. </P>
<P>o Low Field NMR Studies of Atlantic Salmon (Salmo salar). </P>
<P>o Water Distribution and Mobility in Fish Products in Relation to Quality. </P>
<P>o Proton NMR of Fish Oils and Lipids. </P>
<P>o Determination of Fatty Acid Composition and Oxidation in Fish Oils by High Resolution Nuclear Magnetic Resonance Spectroscopy. </P>
<P>o Resonance Spectroscopy to Study Lipid Oxidation in Fish and Fish Products. </P>
<P>o Omega-3 Fatty Acid Content of Intact Muscle of Farmed Atlantic Salmon (Salmo salar) Examined by <SUP>1</SUP>H MAS NMR Spectroscopy. </P>
<P>o HR MAS NMR Spectroscopy of Marine Microalgae, Part 1: Classification and Metabolite Composition from HR MAS <SUP>1</SUP>H NMR Spectra and Multivariate Analysis. </P>
<P>o HR MAS NMR Spectroscopy of Marine Microalgae, Part 2: <SUP>13</SUP>C and <SUP>13</SUP>C HR MAS NMR Analysis Used to Study Fatty Acid Composition and Polysaccharide Structure. </P>
<P>o Post-mortem Studies of Fish Using Magnetic Resonance Imaging. </P>
<P>o How is the Fish Meat Affected by Technological Processes?</P>
<P>PART II: APPLICATIONS IN MEDICAL & PHARMACEUTICAL SCIENCES</P>
<P>· Medical Sciences:</P>
<P>o Acquiring Neurospectroscopy in Clinical Practice. </P>
<P>o Application of Magnetic Resonance for the Diagnosis of Infective Brain Lesions. </P>
<P>o Application of 2D Magnetic Resonance Spectroscopy to the Study of Human Biopsies. </P>
<P>o Correlation of Histopathology with Magnetic Resonance Spectroscopy of Human Biopsies. </P>
<P>o Functional MRI. </P>
<P>o High Resolution Magic Angle Spinning (HRMAS) Proton MRS of Surgical Specimens. </P>
<P>o Intraoperative MRI. </P>
<P>o In Vivo Magnetic Resonance Spectroscopy in Breast Cancer. </P>
<P>o In Vivo Molecular MR Imaging: Potential and Limits. </P>
<P>o In vivo <SUP>13</SUP>C MRS. </P>
<P>o Magnetic Resonance Spectroscopy and Spectroscopic Imaging of the Prostate, Breast, and Liver. </P>
<P>o MR-Mammography. </P>
<P>o Phosphorus Magnetic Resonance Spectroscopy on Biopsy and In Vivo. </P>
<P>o Radio Frequency Coils for Magnetic Resonance Spectroscopy. </P>
<P>o Spatially Resolved Two-Dimensional MR Spectroscopy in vivo. </P>
<P>· Overview of NMR in the Pharmaceutical Sciences.</P>
<P>· Instrumentation. </P>
<P>o Applications of Cryogenic NMR Probe Technology for the Identification of Low-Level Impurities in Pharmaceuticals. </P>
<P>o Flow NMR Techniques in the Pharmaceutical Sciences. </P>
<P>o Developments in NMR Hyphenation for Pharmaceutical Industry. </P>
<P>o LC-NMR in Dereplication and Structure Elucidation of Herbal Drugs. </P>
<P>· Techniques. </P>
<P>o New Approaches to NMR Data Acquisition, Assignment and Protein Structure Determination: Potential Impact in Drug Discovery. </P>
<P>o Transferred Cross-Correlated Relaxation: Application to Drug/Target Complexes. </P>
<P>o Novel Uses of Paramagnets to Solve Complex Protein Structures. </P>
<P>o Fast Assignments of 15N-HSQC Spectra of Proteins by Paramagnetic Labeling. </P>
<P>o Phospholipid Bicelle Membrane Systems for Studying Drug Molecules. </P>
<P>o Partial Alignment for Structure Determination of Organic Molecules. </P>
<P>o Measurement of Residual Dipolar Couplings and Applications in Protein NMR. </P>
<P>o Using Chemical Shift Perturbations to Validate and Refine the Docking of Novel IgE Antagonists to the High-Affinity IgE Receptor. </P>
<P>o Dual-Region Hadamard-Encoding to Improve Resolution and Save Time. </P>
<P>o Nonuniform Sampling in Biomolecular NMR. </P>
<P>· Applications. </P>
<P>o Structural Characterization of Antimicrobial Peptides by NMR Spectroscopy. </P>
<P>o Pharmaceutical Applications of Ion Channel Blockers: Use of NMR to Determine the Structure of Scorpion Toxins. </P>
<P>o Structure and Dynamics of Inhibitor and Metal Binding to Metallo-ß-Lactamases. </P>
<P>o NMR Spectroscopy in the Analysis of Protein–Protein Interactions. </P>
<P>o Identification and Characterization of Ternary Complexes Using NMR Spectroscopy. </P>
<P>o The Transferred NOE. </P>
<P>o NMR Kinetic Measurements in DNA Folding and Drug Binding. </P>
<P>o The Use of NMR in the Studies of Highly Flexible States of Proteins: Relation to Protein Function and Stability. </P>
<P>o NMR-based Metabonomics Techniques and Applications. </P>
<P>o Protein Misfolding Disease: Overview of Liquid and Solid-State High Resolution NMR Studies. </P>
<P>o <SUP>19</SUP>F NMR Spectroscopy for Functional and Binding High-Throughput Screening. </P>
<P>o Applications of Receptor-Based NMR Screening in Drug Discovery. </P>
<P>o NMR SHAPES Screening. </P>
<P>o NMR-Based Screening Applied to Drug Discovery Targets. </P>
<P>o NMR and Structural Genomics in the Pharmaceutical Sciences.</P>
<P>PART III: APPLICATIONS IN MATERIALS SCIENCE & FOOD SCIENCE</P>
<P>· Materials Science</P>
<P>o Acoustically Stimulated NMR Relaxometry: Application to the Study of Molecular Dynamics in Liquid Crystalline Materials. </P>
<P>o Characterization of Elastomers Based on Monitoring Ultraslow Dipolar Correlations by NMR. </P>
<P>o Correlating Molecular and Macroscopic Properties of Elastomers by NMR Relaxometry and Multi-pulse NMR Techniques. </P>
<P>o Determining Structural and Dynamic Distribution Functions from Inhomogeneously Broadened NMR Spectra: The Conjugate Orthogonal Functions Approach. </P>
<P>o Fluid Diffusion in Partially Filled Nanoscopic and Microscopic Porous Materials. </P>
<P>o Gas Adsorption on Carbon Nanotubes. </P>
<P>o Magnetic Resonance Studies of the Heterogeneous Rotational and Translational dynamics in Disordered Materials. </P>
<P>o Nuclear Magnetic Resonance in Ferromagnetic Multilayers and Nanocomposites: Investigations of Their Structural and Magnetic Properties. </P>
<P>o <SUP>1</SUP>H Solid-State NMR of Supramolecular Systems. </P>
<P>o Quadrupolar NMR of Inorganic Materials: The Multiple-Quantum Magic Angle Spinning Experiment. </P>
<P>o Rheo-NMR Spectroscopy. </P>
<P>o Advances in Single-Sided NMR. </P>
<P>o Site-specific Characterization of Structure and Dynamics of Complex Materials by EPR Spin Probes. </P>
<P>o NMR of Organic Semiconductors. </P>
<P>o Solid State NMR of Xerogels. </P>
<P>o Solid-State 17O NMR Spectroscopy of High-Pressure Silicates. </P>
<P>o The Structure of Oxide Glasses: Insights from <SUP>17</SUP>O NMR. </P>
<P>o Studies of the Local Structure of Silk Using Solid-State NMR. </P>
<P>o Velocity Imaging of Granular Materials. </P>
<P>· Food Science</P>
<P>· High Resolution Solution State Methods. </P>
<P>o Characterization of the Chemical Composition of Beverages by NMR Spectroscopy. </P>
<P>o High Resolution NMR of Carrageenans. </P>
<P>o Flavor–Food Compound Interactions by NMR Spectroscopy. </P>
<P>o High-Resolution Nuclear Magnetic Resonance Spectroscopy of Fruit Juices. </P>
<P>o High-Resolution NMR Spectroscopy in Human Metabolism and Metabonomics.</P>
<P>o High-Resolution NMR of Milk and Milk Proteins. </P>
<P>o High-Resolution <SUP>13</SUP>C Nuclear Magnetic Resonance in the Study of Oils. </P>
<P>o High-Resolution <SUP>1</SUP>H Nuclear Magnetic Resonance in the Study of Oils. </P>
<P>o SNIF-NMR—Part 1: Principles. </P>
<P>o SNIF-NMR—Part 2: Isotope Ratios as Tracers of Chemical and Biochemical Mechanistic Pathways. </P>
<P>o SNIF-NMR—Part 3: From Mechanistic Affiliation to Origin Inference. </P>
<P>o SNIF-NMR—Part 4: Applications in an Economic Context: The Example of Wines, Spirits, and Juices. </P>
<P>o High-Resolution Nuclear Magnetic Resonance Spectroscopy of Wine, Beer, and Spirits. </P>
<P>· Relaxation Time Methods. </P>
<P>o NMR Relaxation of Dairy Products. </P>
<P>o Characterization of Molecular Mobility in Carbohydrate Food Systems by NMR. </P>
<P>o Diffusion and Relaxation in Gels. </P>
<P>o NMR Relaxation and Diffusion Studies of Horticultural Products. </P>
<P>o Proton NMR Relaxometry in Meat Science. </P>
<P>o Time-Domain NMR in Quality Control: More Advanced Methods. </P>
<P>o Time-Domain NMR in Quality Control: Standard Applications in Food. </P>
<P>o Nuclear Magnetic Relaxation in Starch Systems. </P>
<P>· High Resolution Solid State Methods. </P>
<P>o Magic Angle Spinning NMR of Flours and Doughs. </P>
<P>o High-Resolution Magic Angle Spinning NMR Spectroscopy of Fruits and Vegetables. </P>
<P>o High-Resolution Solid-State NMR of Gluten and Dough. </P>
<P>o High-Resolution Solid-State NMR as an Analytical Tool to Study Plant Seeds. High-Resolution Solid-State NMR Spectroscopy of Starch Polysaccharides. </P>
<P>· Imaging and Related Techniques. </P>
<P>o NMR Imaging of Bread and Biscuit. </P>
<P>o NMR Imaging of Dairy Products. </P>
<P>o NMR Imaging of Dough. </P>
<P>o MRI in Food Process Engineering. </P>
<P>o Rheo-NMR: Applications to Food. </P>
<P>o Temperature Measurements by Magnetic Resonance. </P>
<P>· Statistical Methods. </P>
<P>o Chemometric Analysis of NMR Data. </P>
<P>o Direct Exponential Curve Resolution by SLICING. </P>
<P>· ESR Methods. </P>
<P>o ESR as a Technique for Food Irradiation Detection. </P>
<P>o ESR Spectroscopy for the Study of Oxidative Processes in Food and Beverages. </P>
<P>· Applications to Food Systems. </P>
<P>o Magnetic Resonance Studies of Food Freezing. </P>
<P>o Nuclear Magnetic Resonance Studies on the Glass Transition and Crystallization in Low Moisture Sugars. </P>
<P>o Probing the Sensory Properties of Food Materials with Nuclear Magnetic Resonance Spectroscopy and Imaging. </P>
<P>o Single-Sided NMR in Foods. </P>
<P>o Applications of NMR in the Studies of Starch Systems.</P>