<p>PART 1 Disease forms and animal models of hypophosphatasia<br>1 Clinical forms and animal models of hypophosphatasia<br>2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations <br>Etienne MORNET <br>3 Genetically modified mice for studying TNAP function<br>Sonoko NARISAWA<br><br>PART 2 Expression and regulation of TNAP in the CNS<br>4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis<br>Herbert Zimmermann and David Langer<br>5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex<br>Caroline Fonta, Pascal Barone, Laia Rodriguez Martinez and László Négyessy<br>6 TNAP in the retina<br>Orsolya Kántor, Dorottya Cserpán, Béla Völgyi, Ákos Lukáts, Zoltán Somogyvári<br>7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain <br>Barbara Deracinois, Anne-Marie Lenfant, Marie-Pierre Dehouck <sup> </sup>and Christophe Flahaut<br><br>PART 3 TNAP functions in the nervous system<br>8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? <br>José Luis Millán<br>9 TNAP, an essential player in membrane lipid rafts of neuronal cells<br>Myriam Ermonval, Florence Baychelier, Caroline Fonta<br>10 Signal transduction pathways of TNAP: molecular network analyses<br>Négyessy L, Györffy B, Hanics J, Bányai M, Ermonval M, Fonta C, Bazsó F <br>11 Vitamin B-6 Metabolism and Interactions with TNAP<br>Stephen P. Coburn<br>12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex <br>Lionel G. Nowak, Benoît Rosay, David Czégé, Caroline Fonta <br>13 TNAP and Pain Control<br>Sarah E. Street and Nathaniel A. Sowa<br><br>PART 4 TNAP in neurological disorders<br>14 Neurological symptoms of Hypophosphatasia<br>Takeshi Taketani<br>15 Recombinant enzyme replacement therapy in hypophosphatasia<br>Hofmann C, Jakob F, Seefried L, Mentrup B, Graser S, Plotkin H, Girschick HJ, Liese J<br>16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome<br>David E.C. Cole and Miles D. Thompson<br>17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer’s disease in the focus<br>Katherine AB Kellett & Nigel M Hooper<br>18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders<br>Diaz-Hernandez M, Hernandez F, Miras-Portugal M.T.<sup> </sup> and Avila J<br>Index</p>
